Mammalian Sirtuins--emerging Roles in Physiology, Aging, and Calorie Restriction

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2006 Nov 3

PMID 17079682

Citations 598

Authors

Marcia C Haigis

Leonard P Guarente

Affiliations

Soon will be listed here.

Abstract

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.

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