Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

Overview

Journal Science

Specialty Science

Date 1975 Oct 3

PMID 170678

Citations 102

Authors

J S Flier

C R Kahn

J Roth

R S Bar

Affiliations

Soon will be listed here.

Abstract

Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.

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