3-aminoquinazolinediones As a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-type and Multidrug Resistant Organisms

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2006 Oct 27

PMID 17064062

Citations 18

Authors

Edmund L Ellsworth

Tuan P Tran

H D Hollis Showalter

Joseph P Sanchez

Brian M Watson

Michael A Stier

John M Domagala

Stephen J Gracheck

E Themis Joannides

Martin A Shapiro

Steve A Dunham

Debra L Hanna

Michael D Huband

Jeffrey W Gage

Joel C Bronstein

Jia Yeu Liu

Dai Q Nguyen

Rajeshwar Singh

Affiliations

Soon will be listed here.

Abstract

The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial gyrase and topoisomerase IV and demonstrate clinically useful antibacterial activity against fastidious Gram-negative and Gram-positive organisms, including multidrug- and fluoroquinolone-resistant organisms. These agents also demonstrate in vivo efficacy in murine systemic infection models.

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