Immunopathology of Intraocular Silicone Oil: Retina and Epiretinal Membranes

Overview

Journal Br J Ophthalmol

Specialty Ophthalmology

Date 2006 Sep 29

PMID 17005544

Citations 16

Authors

Louisa J Wickham

Riaz H Asaria

Robert Alexander

Phil Luthert

David G Charteris

Affiliations

Soon will be listed here.

Abstract

Aims: To determine the inflammatory response in retina and epiretinal membranes after intraocular silicone oil tamponade.

Methods: 14 proliferative vitreoretinopathy (PVR) epiretinal membranes, 33 retro-oil epiretinal membranes, 19 retinectomies, 14 retro-oil retinectomies and 37 idiopathic epiretinal membranes (controls) underwent immunohistochemical analysis using the avidin-biotin complex technique and a panel of monoclonal and polyclonal antibodies. The number of positive cells counted in five 0.5 mm diameter fields of immunohistochemical sections was graded on a score of 1-4.

Results: Macrophage cell counts were significantly greater in membranes with a history of exposure to silicone oil (p<0.001). An inflammatory response could be observed within 1 month of silicone oil exchange, and the intensity seemed to be unrelated to the duration of exposure. Macrophages were confined to epiretinal membranes on the surface of retinectomy specimens in 10 of 14 cases and intraretinal macrophages were observed only in specimens with gliotic retina. T and B lymphocytes were rarely seen in the specimens examined. Marked glial cell up regulation was observed in 11 of 16 retinectomy specimens and in 8 of 11 retro-oil retinectomies. Glial cell content was variable in the membranes, but there was a trend of increased presence after exposure to silicone oil.

Conclusion: This study has shown that the use of silicone oil is accompanied by an inflammatory reaction, primarily mediated by bloodborne macrophages. This response can be observed within 1 month of silicone oil injection and continues after silicone oil removal. Retinal surgeons should be aware of the potential secondary effects of intraocular silicone oil when they are considering its use (and removal) in vitreoretinal surgery.

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References

Eller A, Friberg T, Mah F . Migration of silicone oil into the brain: a complication of intraocular silicone oil for retinal tamponade. Am J Ophthalmol. 2000; 129(5):685-8. DOI: 10.1016/s0002-9394(00)00368-8. View

Honavar S, Goyal M, Majji A, Sen P, Naduvilath T, Dandona L . Glaucoma after pars plana vitrectomy and silicone oil injection for complicated retinal detachments. Ophthalmology. 1999; 106(1):169-76; discussion 177. DOI: 10.1016/S0161-6420(99)90017-9. View

Budde M, Cursiefen C, Holbach L, Naumann G . Silicone oil-associated optic nerve degeneration. Am J Ophthalmol. 2001; 131(3):392-4. DOI: 10.1016/s0002-9394(00)00800-x. View

Srinivasan S, Singh A, Desai S, Talbot J, Parsons M . Foreign body episcleral granulomas complicating intravitreal silicone oil tamponade: a clinicopathological study. Ophthalmology. 2003; 110(9):1837-40. DOI: 10.1016/S0161-6420(03)00571-2. View

Chung J, Spaide R . Intraretinal silicone oil vacuoles after macular hole surgery with internal limiting membrane peeling. Am J Ophthalmol. 2003; 136(4):766-7. DOI: 10.1016/s0002-9394(03)00450-1. View

Betis F, Leguay J, Gastaud P, Hofman P . Multinucleated giant cells in periretinal silicone granulomas are associated with progressive proliferative vitreoretinopathy. Eur J Ophthalmol. 2003; 13(7):634-41. DOI: 10.1177/112067210301300707. View

Asaria R, Kon C, Bunce C, Sethi C, Limb G, Khaw P . Silicone oil concentrates fibrogenic growth factors in the retro-oil fluid. Br J Ophthalmol. 2004; 88(11):1439-42. PMC: 1772397. DOI: 10.1136/bjo.2003.040402. View

Watzke R . Silicone retinopiesis for retinal detachment. A long-term clinical evaluation. Arch Ophthalmol. 1967; 77(2):185-96. DOI: 10.1001/archopht.1967.00980020187008. View

Ni C, Wang W, Albert D, Schepens C . Intravitreous silicone injection. Histopathologic findings in a human eye after 12 years. Arch Ophthalmol. 1983; 101(9):1399-401. DOI: 10.1001/archopht.1983.01040020401013. View

10.

Hiscott P, Grierson I, McLeod D . Natural history of fibrocellular epiretinal membranes: a quantitative, autoradiographic, and immunohistochemical study. Br J Ophthalmol. 1985; 69(11):810-23. PMC: 1040751. DOI: 10.1136/bjo.69.11.810. View

11.

Kirchhof B, Tavakolian U, Paulmann H, Heimann K . Histopathological findings in eyes after silicone oil injection. Graefes Arch Clin Exp Ophthalmol. 1986; 224(1):34-7. DOI: 10.1007/BF02144130. View

12.

Parmley V, BARISHAK Y, HOWES Jr E, CRAWFORD J . Foreign-body giant cell reaction to liquid silicone. Am J Ophthalmol. 1986; 101(6):680-3. DOI: 10.1016/0002-9394(86)90768-3. View

13.

Bornfeld N, Laqua H . Ultrastructural characteristics of preretinal membranes from human eyes filled with silicone oil. Am J Ophthalmol. 1987; 103(6):770-5. DOI: 10.1016/s0002-9394(14)74392-2. View

14.

Lewis H, Burke J, Abrams G, AABERG T . Perisilicone proliferation after vitrectomy for proliferative vitreoretinopathy. Ophthalmology. 1988; 95(5):583-91. DOI: 10.1016/s0161-6420(88)33136-2. View

15.

Hiscott P, Unger W, Grierson I, McLeod D . The role of inflammation in the development of epiretinal membranes. Curr Eye Res. 1988; 7(9):877-92. DOI: 10.3109/02713688808997245. View

16.

Jerdan J, Pepose J, Michels R, Hayashi H, De Bustros S, Sebag M . Proliferative vitreoretinopathy membranes. An immunohistochemical study. Ophthalmology. 1989; 96(6):801-10. DOI: 10.1016/s0161-6420(89)32818-1. View

17.

Baudouin C, Gordon W, Baudouin F, Peyman G, Lapalus P, Gastaud P . Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy. Am J Ophthalmol. 1990; 110(6):593-8. DOI: 10.1016/s0002-9394(14)77054-0. View

18.

Foulks G, Hatchell D, Proia A, Klintworth G . Histopathology of silicone oil keratopathy in humans. Cornea. 1991; 10(1):29-37. View

19.

Nicolai U, Eckardt C . [Immunohistochemical findings of epiretinal membranes after silicone oil injection]. Fortschr Ophthalmol. 1991; 88(6):660-4. View

20.

Heidenkummer H, Kampik A . Intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) expression in human epiretinal membranes. Graefes Arch Clin Exp Ophthalmol. 1992; 230(5):483-7. DOI: 10.1007/BF00175938. View