Water-soluble Poly(ethylenimine)-based Nitric Oxide Donors: Preparation, Characterization, and Potential Application in Hemodialysis

Overview

Journal Biomacromolecules

Publisher American Chemical Society

Specialties Biochemistry
Biology
Molecular Biology

Date 2006 Sep 12

PMID 16961319

Citations 11

Authors

Zhengrong Zhou

Gail M Annich

Yiduo Wu

Mark E Meyerhoff

Affiliations

Soon will be listed here.

Abstract

A novel approach to potentially resolve serious thrombosis issues associated with kidney dialysis (hemodialysis) therapies is described. New water-soluble polymeric nitric oxide (NO) donors, based on the diazeniumdiolated branched poly(ethylenimine)s and their derivatives, are prepared and characterized. These macromolecular NO donors (with up to 4.15 micromol/mg of total NO release) are utilized as additives to the dialysate solution of model dialysis filters. The presence of these species can create a localized increase in NO levels at the high surface area dialysis fiber/blood interface within the hemodialyzers. Nitric oxide is a naturally occurring and potent anti-platelet agent and is expected to greatly decrease the risk of thrombosis in the dialysis units.

Citing Articles

Structural heterogeneity in polymeric nitric oxide donor nanoblended coatings for controlled release behaviors.

Jeong H, Park K, Yoo J, Hong J RSC Adv. 2022; 8(68):38792-38800.

PMID: 35558288 PMC: 9090654. DOI: 10.1039/c8ra07707j.

-nitrosothiol-modified hyperbranched polyesters.

Yang L, Lu Y, Soto R, Shah A, Ahonen M, Schoenfisch M Polym Chem. 2021; 7(46):7161-7169.

PMID: 34276815 PMC: 8281897.

Nitric oxide-releasing hyperbranched polyaminoglycosides for antibacterial therapy.

Yang L, Schoenfisch M ACS Appl Bio Mater. 2020; 1(4):1066-1073.

PMID: 32309793 PMC: 7164780. DOI: 10.1021/acsabm.8b00304.

In Vivo Antibacterial Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers against .

Yang L, Jing L, Jiao Y, Wang L, Marchesan J, Offenbacher S Mol Pharm. 2019; 16(9):4017-4023.

PMID: 31361146 PMC: 6752707. DOI: 10.1021/acs.molpharmaceut.9b00671.

Antimicrobial activity of NO-releasing compounds against periodontal pathogens.

Shim J, Park D, Baek D, Jha N, Park S, Yun H PLoS One. 2018; 13(10):e0199998.

PMID: 30286117 PMC: 6171828. DOI: 10.1371/journal.pone.0199998.

References

Batchelor M, Reoma S, Fleser P, Nuthakki V, Callahan R, Shanley C . More lipophilic dialkyldiamine-based diazeniumdiolates: synthesis, characterization, and application in preparing thromboresistant nitric oxide release polymeric coatings. J Med Chem. 2003; 46(24):5153-61. DOI: 10.1021/jm030286t. View

Mowery K, Schoenfisch M, Saavedra J, Keefer L, Meyerhoff M . Preparation and characterization of hydrophobic polymeric films that are thromboresistant via nitric oxide release. Biomaterials. 2000; 21(1):9-21. DOI: 10.1016/s0142-9612(99)00127-1. View

Monien B, Desai U . Antithrombin activation by nonsulfated, non-polysaccharide organic polymer. J Med Chem. 2005; 48(4):1269-73. DOI: 10.1021/jm0492960. View

Annich G, Meinhardt J, Mowery K, Ashton B, Merz S, Hirschl R . Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers. Crit Care Med. 2000; 28(4):915-20. DOI: 10.1097/00003246-200004000-00001. View

Pinnick R, Wiegmann T, DIEDERICH D . Regional citrate anticoagulation for hemodialysis in the patient at high risk for bleeding. N Engl J Med. 1983; 308(5):258-61. DOI: 10.1056/NEJM198302033080506. View

Nablo B, Prichard H, Butler R, Klitzman B, Schoenfisch M . Inhibition of implant-associated infections via nitric oxide release. Biomaterials. 2005; 26(34):6984-90. DOI: 10.1016/j.biomaterials.2005.05.017. View

Radomski M, Palmer R, Moncada S . The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun. 1987; 148(3):1482-9. DOI: 10.1016/s0006-291x(87)80299-1. View

Nablo B, Rothrock A, Schoenfisch M . Nitric oxide-releasing sol-gels as antibacterial coatings for orthopedic implants. Biomaterials. 2004; 26(8):917-24. DOI: 10.1016/j.biomaterials.2004.03.031. View

Zhou Z, Meyerhoff M . Preparation and characterization of polymeric coatings with combined nitric oxide release and immobilized active heparin. Biomaterials. 2005; 26(33):6506-17. DOI: 10.1016/j.biomaterials.2005.04.046. View

10.

Frost M, Meyerhoff M . Synthesis, characterization, and controlled nitric oxide release from S-nitrosothiol-derivatized fumed silica polymer filler particles. J Biomed Mater Res A. 2005; 72(4):409-19. DOI: 10.1002/jbm.a.30275. View

11.

Radomski M, Palmer R, Moncada S . The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol. 1987; 92(3):639-46. PMC: 1853691. DOI: 10.1111/j.1476-5381.1987.tb11367.x. View

12.

Lohr J, Schwab S . Minimizing hemorrhagic complications in dialysis patients. J Am Soc Nephrol. 1991; 2(5):961-75. DOI: 10.1681/ASN.V25961. View

13.

Faber L, de Vries P, Oe P, van der Meulen J, Donker A . Citrate haemodialysis. Neth J Med. 1990; 37(5-6):219-24. View

14.

Frost M, Rudich S, Zhang H, Maraschio M, Meyerhoff M . In vivo biocompatibility and analytical performance of intravascular amperometric oxygen sensors prepared with improved nitric oxide-releasing silicone rubber coating. Anal Chem. 2002; 74(23):5942-7. DOI: 10.1021/ac025944g. View

15.

Siney L, Lewis M . Endothelium-derived relaxing factor inhibits platelet adhesion to cultured porcine endocardial endothelium. Eur J Pharmacol. 1992; 229(2-3):223-6. DOI: 10.1016/0014-2999(92)90559-m. View

16.

Ueda T, Maekawa T, Sadamitsu D, Oshita S, Ogino K, Nakamura K . The determination of nitrite and nitrate in human blood plasma by capillary zone electrophoresis. Electrophoresis. 1995; 16(6):1002-4. DOI: 10.1002/elps.11501601167. View

17.

Sneddon J, Vane J . Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells. Proc Natl Acad Sci U S A. 1988; 85(8):2800-4. PMC: 280087. DOI: 10.1073/pnas.85.8.2800. View

18.

Fleser P, Nuthakki V, Malinzak L, Callahan R, Seymour M, Reynolds M . Nitric oxide-releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts. J Vasc Surg. 2004; 40(4):803-11. DOI: 10.1016/j.jvs.2004.07.007. View

19.

Espey M, Miranda K, Thomas D, Wink D . Ingress and reactive chemistry of nitroxyl-derived species within human cells. Free Radic Biol Med. 2002; 33(6):827-34. DOI: 10.1016/s0891-5849(02)00978-4. View

20.

Kim Y . Anticoagulation during haemodialysis in patients at high-risk of bleeding. Nephrology (Carlton). 2004; 8 Suppl:S23-7. DOI: 10.1046/j.1440-1797.8.s.3.x. View