Toll-like Receptors and IFN-alpha: Partners in Autoimmunity

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2006 Sep 7

PMID 16955132

Citations 13

Authors

Marco Colonna

Affiliations

Soon will be listed here.

Abstract

Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion of self-reactive T cells but also activate antigen-presenting cells through TLR stimulation (see the related article beginning on page 2456). Activated cells then secrete IFN-alpha and TNF-alpha, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage.

Citing Articles

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Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy.

Zheng N, Wang B, Fan J, Luo N, Kong Q, Ye H Mediators Inflamm. 2018; 2017:4532409.

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Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man.

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Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers.

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Prevention or acceleration of type 1 diabetes by viruses.

Ghazarian L, Diana J, Simoni Y, Beaudoin L, Lehuen A Cell Mol Life Sci. 2012; 70(2):239-55.

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