Differential Inhibition of Lipopolysaccharide-induced Phenomena by Anti-tumor Necrosis Factor Alpha Antibody

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1990 Jul 1

PMID 1694829

Citations 10

Authors

S N Vogel

E A Havell

Affiliations

Soon will be listed here.

Abstract

Tumor necrosis factor alpha (TNF alpha) has been implicated as a major mediator of lipopolysaccharide (LPS)-induced phenomena. Administration to mice of a polyclonal, monospecific antibody prepared against recombinant murine TNF alpha abolished detection of LPS-induced TNF alpha activity and significantly reduced levels of LPS-induced colony-stimulating factor but failed to reduce the production of LPS-induced interferon, corticosterone, or LPS-induced hypoglycemia.

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