The Control of Histone Lysine Methylation in Epigenetic Regulation

Overview

Journal Biochimie

Specialty Biochemistry

Date 2006 Aug 22

PMID 16919862

Citations 84

Authors

Pamela Volkel

Pierre-Olivier Angrand

Affiliations

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Abstract

Histone lysine methylation plays a fundamental role in chromatin organization and function. This epigenetic mark is involved in many biological processes such as heterochromatin formation, chromosome X inactivation, genomic imprinting and transcriptional regulation. Here, we review recent advances in how histone lysine methylation participates in these biological events, and the enzymes that control histone lysine methylation and demethylation.

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