The Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Apr 2

PMID 32230868

Citations 2

Authors

Ludivine Raby

Pamela Volkel

Xuefen Le Bourhis

Pierre-Olivier Angrand

Affiliations

Soon will be listed here.

Abstract

The Polycomb Repressive Complex 1 (PRC1) is a chromatin-associated protein complex involved in transcriptional repression of hundreds of genes controlling development and differentiation processes, but also involved in cancer and stem cell biology. Within the canonical PRC1, members of Pc/CBX protein family are responsible for the targeting of the complex to specific gene loci. In mammals, the Pc/CBX protein family is composed of five members generating, through mutual exclusion, different PRC1 complexes with potentially distinct cellular functions. Here, we performed a global analysis of the gene family in 68 teleost species and traced the distribution of the genes through teleost evolution in six fish super-orders. We showed that after the teleost-specific whole genome duplication, , and are retained as pairs of ohnologues. In contrast, and are present as pairs of ohnologues in the genome of several teleost clades but as singletons in others. Furthermore, since zebrafish is a widely used vertebrate model for studying development, we report on the expression of the family members during zebrafish development and in adult tissues. We showed that all genes are ubiquitously expressed with some variations during early development.

Citing Articles

The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates.

Hanot M, Raby L, Volkel P, Le Bourhis X, Angrand P Int J Mol Sci. 2023; 24(3).

PMID: 36768643 PMC: 9916924. DOI: 10.3390/ijms24032322.

Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.

Raby L, Volkel P, Hasanpour S, Cicero J, Toillon R, Adriaenssens E Cells. 2021; 10(11).

PMID: 34831364 PMC: 8620594. DOI: 10.3390/cells10113142.

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