Farnesoid X-activated Receptor Antagonists from a Marine Sponge Spongia Sp

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2006 Aug 15

PMID 16905319

Citations 12

Authors

Sang-Jip Nam

Hyunsil Ko

Mihee Shin

Jungyeob Ham

Jungwook Chin

Youngshin Kim

Heeyoung Kim

Kyoungjin Shin

Hyukjae Choi

Heonjoong Kang

Affiliations

Soon will be listed here.

Abstract

Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

Citing Articles

Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis.

Ding C, Wang Z, Dou X, Yang Q, Ning Y, Kao S Aging Dis. 2023; 15(4):1508-1536.

PMID: 37815898 PMC: 11272191. DOI: 10.14336/AD.2023.0830.

Farnesoid X receptor regulators from natural products and their biological function.

Wan P, Hengfan N, Dale G, Yun D, Manyun D J Tradit Chin Med. 2023; 43(3):618-626.

PMID: 37147766 PMC: 10133962. DOI: 10.19852/j.cnki.jtcm.20230404.002.

Isolation of Scalimides A-L: -Alanine-Bearing Scalarane Analogs from the Marine Sponge sp.

Shin A, Lee H, Lee J Mar Drugs. 2022; 20(11).

PMID: 36422004 PMC: 9695134. DOI: 10.3390/md20110726.

Natural Products Targeting Liver X Receptors or Farnesoid X Receptor.

She J, Gu T, Pang X, Liu Y, Tang L, Zhou X Front Pharmacol. 2022; 12:772435.

PMID: 35069197 PMC: 8766425. DOI: 10.3389/fphar.2021.772435.

Antibacterial scalarane from nudibranchs (Gastropoda, Nudibranchia), egg ribbons, and their dietary sponge cf. (Demospongiae, Dictyoceratida).

Hertzer C, Kehraus S, Bohringer N, Kaligis F, Bara R, Erpenbeck D Beilstein J Org Chem. 2020; 16:1596-1605.

PMID: 32704326 PMC: 7356558. DOI: 10.3762/bjoc.16.132.