Enigma Variations: Control of Sexual Fate in Nematode Germ Cells

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2006 Aug 2

PMID 16879734

Authors

Ronald E Ellis

Affiliations

Soon will be listed here.

Abstract

A new study showing that neither FEM-2 nor FEM-3 is required for spermatogenesis in Caenorhabditis briggsae, unlike in Caenorhabditis elegans, implies that the sex-determination pathway in these species is evolving rapidly, and supports the proposal that they evolved hermaphroditism independently.

References

Haag E, Wang S, Kimble J . Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2. Curr Biol. 2002; 12(23):2035-41. DOI: 10.1016/s0960-9822(02)01333-7. View

RAYMOND C, Shamu C, Shen M, Seifert K, Hirsch B, Hodgkin J . Evidence for evolutionary conservation of sex-determining genes. Nature. 1998; 391(6668):691-5. DOI: 10.1038/35618. View

Nayak S, Goree J, Schedl T . fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis. PLoS Biol. 2005; 3(1):e6. PMC: 539060. DOI: 10.1371/journal.pbio.0030006. View

Hill R, Egydio de Carvalho C, Salogiannis J, Schlager B, Pilgrim D, Haag E . Genetic flexibility in the convergent evolution of hermaphroditism in Caenorhabditis nematodes. Dev Cell. 2006; 10(4):531-8. DOI: 10.1016/j.devcel.2006.02.002. View

Chen P, Ellis R . TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans. Development. 2000; 127(14):3119-29. DOI: 10.1242/dev.127.14.3119. View

Clifford R, Lee M, Nayak S, Ohmachi M, Giorgini F, Schedl T . FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline. Development. 2000; 127(24):5265-76. DOI: 10.1242/dev.127.24.5265. View

Lum D, Kuwabara P, Zarkower D, Spence A . Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans. Genes Dev. 2000; 14(24):3153-65. PMC: 317132. View

Wang S, Kimble J . The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans. EMBO J. 2001; 20(6):1363-72. PMC: 145520. DOI: 10.1093/emboj/20.6.1363. View

Chen P, Cho S, Jin S, Ellis R . Specification of germ cell fates by FOG-3 has been conserved during nematode evolution. Genetics. 2001; 158(4):1513-25. PMC: 1461761. DOI: 10.1093/genetics/158.4.1513. View

10.

Tan K, Chan S, Tan K, Yu V . The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. J Biol Chem. 2001; 276(47):44193-202. DOI: 10.1074/jbc.M105880200. View

11.

Stothard P, Hansen D, Pilgrim D . Evolution of the PP2C family in Caenorhabditis: rapid divergence of the sex-determining protein FEM-2. J Mol Evol. 2002; 54(2):267-82. DOI: 10.1007/s0023901-0008-y. View

12.

Goodwin E, Ellis R . Turning clustering loops: sex determination in Caenorhabditis elegans. Curr Biol. 2002; 12(3):R111-20. DOI: 10.1016/s0960-9822(02)00675-9. View

13.

Kiontke K, Gavin N, Raynes Y, Roehrig C, Piano F, Fitch D . Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss. Proc Natl Acad Sci U S A. 2004; 101(24):9003-8. PMC: 428462. DOI: 10.1073/pnas.0403094101. View

14.

Cho S, Jin S, Cohen A, Ellis R . A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution. Genome Res. 2004; 14(7):1207-20. PMC: 442136. DOI: 10.1101/gr.2639304. View

15.

Doniach T . Activity of the sex-determining gene tra-2 is modulated to allow spermatogenesis in the C. elegans hermaphrodite. Genetics. 1986; 114(1):53-76. PMC: 1202941. DOI: 10.1093/genetics/114.1.53. View

16.

Spence A, Coulson A, Hodgkin J . The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions. Cell. 1990; 60(6):981-90. DOI: 10.1016/0092-8674(90)90346-g. View

17.

Ahringer J, Rosenquist T, Lawson D, Kimble J . The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally. EMBO J. 1992; 11(6):2303-10. PMC: 556697. DOI: 10.1002/j.1460-2075.1992.tb05289.x. View

18.

Kuwabara P, Okkema P, Kimble J . tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway. Mol Biol Cell. 1992; 3(4):461-73. PMC: 275596. DOI: 10.1091/mbc.3.4.461. View

19.

Pilgrim D, McGregor A, Jackle P, Johnson T, Hansen D . The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase. Mol Biol Cell. 1995; 6(9):1159-71. PMC: 301274. DOI: 10.1091/mbc.6.9.1159. View

20.

Spence A . Caenorhabditis elegans sex-determining protein FEM-2 is a protein phosphatase that promotes male development and interacts directly with FEM-3. Genes Dev. 1996; 10(18):2314-25. DOI: 10.1101/gad.10.18.2314. View