Synthesis and Anti-hepatitis B Virus Activity of Novel Benzimidazole Derivatives

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2006 Jul 21

PMID 16854087

Citations 10

Authors

Yun-Fei Li

Gui-Feng Wang

Pei-Lan He

Wei-Gang Huang

Feng-Hua Zhu

He-yong Gao

Wei Tang

Yu Luo

Chun-Lan Feng

Li-Ping Shi

Yu-Dan Ren

Wei Lu

Jian-Ping Zuo

Affiliations

Soon will be listed here.

Abstract

A series of novel benzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in vitro. Strong activity against HBV replication and low cytotoxicity were generally observed in these benzimidazoles. The most promising compounds were 12a and 12b, with similar high antiviral potency (IC50 = 0.9 and 0.7 microM, respectively) and remarkable selectivity indices (>1111 and 714, respectively). They were selected for further evaluation as novel HBV inhibitors.

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