Synthesis and Insight into the Structure-activity Relationships of 2-phenylbenzimidazoles As Prospective Anticancer Agents

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35517717

Authors

Thi-Kim-Chi Huynh

Thi-Hong-An Nguyen

Thi-Cam-Thu Nguyen

Thi-Kim-Dung Hoang

Affiliations

Soon will be listed here.

Abstract

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC values 4.47, 4.68 and 5.50 μg mL, respectively). In addition, compound 40 exhibited the best IC value of 3.55 μg mL against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.

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