Improving Mass Spectrometer Sensitivity Using a High-pressure Electrodynamic Ion Funnel Interface

Overview

Journal J Am Soc Mass Spectrom

Specialty Chemistry

Date 2006 Jul 15

PMID 16839773

Citations 42

Authors

Yehia Ibrahim

Keqi Tang

Aleksey V Tolmachev

Alexandre A Shvartsburg

Richard D Smith

Affiliations

Soon will be listed here.

Abstract

We report on a new electrodynamic ion funnel that operates at a pressure of 30 torr with no loss of ion transmission. The enhanced performance compared with previous ion funnel designs optimized for pressures of <5 torr was achieved by reducing the ion funnel capacitance and increasing the RF drive frequency (1.7 MHz) and amplitude (100-170 V peak-to-peak). No degradation of ion transmission was observed for pressures from 2 to 30 torr. The ability to operate at higher pressure enabled a new tandem ion funnel mass spectrometer interface design that can accommodate a greater gas load (e.g., from an ESI source). When combined with a multicapillary inlet, the interface provided more efficient introduction of ions, resulting in a significant enhancement in mass spectrometer sensitivity and detection limits.

Citing Articles

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Improving Signal to Noise Ratios in Ion Mobility Spectrometry and Structures for Lossless Ion Manipulations (SLIM) using a High Dynamic Range Analog-to-Digital Converter.

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