Dissociating Apathy and Depression in Parkinson Disease

Overview

Journal Neurology

Specialty Neurology

Date 2006 Jul 13

PMID 16832074

Citations 87

Authors

L Kirsch-Darrow

H H Fernandez

H F Fernandez

M Marsiske

M S Okun

D Bowers

Affiliations

Soon will be listed here.

Abstract

Objective: To examine the hypothesis that apathy is a core feature of Parkinson disease (PD) and that apathy can be dissociated from depression.

Methods: Eighty patients with PD and 20 patients with dystonia completed depression and apathy measures including the Marin Apathy Evaluation Scale (AES), Beck Depression Inventory (BDI), and Centers for Epidemiologic Studies-Depression Scale (CES-D).

Results: There was a significantly higher severity and frequency of apathy in PD (frequency = 51%, 41/80) than in dystonia (frequency = 20%, 4/20). Apathy in the absence of depression was frequent in PD and did not occur in dystonia (PD = 28.8%, dystonia = 0%).

Conclusions: Patients with Parkinson disease (PD) experienced significantly higher frequency and severity of apathy when compared with patients with dystonia. Apathy may be a "core" feature of PD and occurs in the absence of depression.

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