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FREALIGN: High-resolution Refinement of Single Particle Structures

Overview
Journal J Struct Biol
Date 2006 Jul 11
PMID 16828314
Citations 281
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Abstract

The refinement of three-dimensional reconstructions and correction for the contrast transfer function of the microscope are important steps in the determination of macromolecular structures by single particle electron microscopy. The algorithms implemented in the computer program FREALIGN are optimized to perform these tasks efficiently. A general overview and details on how to use FREALIGN are provided. The program is free and available for download on the author's web page.

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