Hydrazides of Clozapine: a New Class of D1 Dopamine Receptor Subtype Selective Antagonists

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2006 Jul 1

PMID 16809034

Citations 2

Authors

T K Sasikumar

D A Burnett

H Zhang

A Smith-Torhan

A Fawzi

J E Lachowicz

Affiliations

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Abstract

Acylated and aroylated hydrazinoclozapines are highly potent dopamine D(1) antagonists that show remarkable selectivity over other dopamine receptors. The most potent compound in this series is the 2,6-dimethoxybenzhydrazide 33 with a D(1)K(i) of 1.6 nM and 212-fold selectivity over D(2) receptor.

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