Centrosome Amplification in Adult T-cell Leukemia and Human T-cell Leukemia Virus Type 1 Tax-induced Human T Cells

Overview

Journal Cancer Sci

Specialty Oncology

Date 2006 Jun 30

PMID 16805820

Citations 18

Authors

Takayuki Nitta

Masayuki Kanai

Eiji Sugihara

Masakazu Tanaka

Binlian Sun

Toshiro Nagasawa

Shunro Sonoda

Hideyuki Saya

Masanao Miwa

Affiliations

Soon will be listed here.

Abstract

Centrosomes play pivotal roles in cell polarity, regulation of the cell cycle and chromosomal segregation. Centrosome amplification was recently described as a possible cause of aneuploidy in certain solid tumors and leukemias. ATL is a T-cell malignancy caused by HTLV-1. Although the precise mechanism of cell transformation is unclear, the HTLV-1-encoded protein, Tax, is thought to play a crucial role in leukemogenesis. Here we demonstrate that lymphocytes isolated from patients with ATL show centrosome amplification and that a human T cell line shows centrosome amplification after induction of Tax, which was suppressed by CDK inhibitors. Micronuclei formation was also observed after centrosome amplification in Tax-induced human T cells. These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV-1 and chromosomal instability in HTLV-1-infected human T cells.

Citing Articles

Mechanisms of Oncogenesis by HTLV-1 Tax.

Mohanty S, Harhaj E Pathogens. 2020; 9(7).

PMID: 32645846 PMC: 7399876. DOI: 10.3390/pathogens9070543.

HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model".

Nicot C J Cancer Sci. 2016; 2(2).

PMID: 26835512 PMC: 4729388. DOI: 10.13188/2377-9292.1000009.

The GTPase RAN regulates multiple steps of the centrosome life cycle.

Lavia P Chromosome Res. 2016; 24(1):53-65.

PMID: 26725228 DOI: 10.1007/s10577-015-9514-4.

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.

Ho Y, Zhi H, Bowlin T, Dorjbal B, Philip S, Zahoor M PLoS Pathog. 2015; 11(8):e1005102.

PMID: 26285145 PMC: 4540474. DOI: 10.1371/journal.ppat.1005102.

Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia.

Nicot C J Oncol. 2015; 2015:183590.

PMID: 26170835 PMC: 4478360. DOI: 10.1155/2015/183590.

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