The HTLV-1 Tax Interactome

Overview

Journal Retrovirology

Publisher Biomed Central

Specialty Microbiology

Date 2008 Aug 16

PMID 18702816

Citations 140

Authors

Mathieu Boxus

Jean-Claude Twizere

Sebastien Legros

Jean-Francois Dewulf

Richard Kettmann

Luc Willems

Affiliations

Soon will be listed here.

Abstract

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Citing Articles

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