FOXO3a-dependent Regulation of Puma in Response to Cytokine/growth Factor Withdrawal

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2006 Jun 28

PMID 16801400

Citations 230

Authors

Han You

Marc Pellegrini

Katsuya Tsuchihara

Kazuo Yamamoto

Georg Hacker

Miriam Erlacher

Andreas Villunger

Tak W Mak

Affiliations

Soon will be listed here.

Abstract

Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokine withdrawal. Our results suggest that Puma, together with another BH3 only member, Bim, function as FOXO3a downstream targets to mediate a stress response when PI3K/Akt signaling is down-regulated.

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