Disjunction of Conjoined Twins: Cdk1, Cdh1 and Separation of Centrosomes

Overview

Journal Cell Div

Publisher Biomed Central

Date 2006 Jun 24

PMID 16792804

Citations 5

Authors

Karen Crasta

Uttam Surana

Affiliations

Soon will be listed here.

Abstract

Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymerization. In each division cycle, the centrosome is duplicated and the sister-centrosomes move away from each other, forming the two poles of the spindle. While the structure and the duplication of centrosomes have been investigated extensively, the understanding of the control of their segregation remains scant. Recent findings are beginning to yield insights into the regulation of centrosome segregation in yeast and its link to the mitotic kinase.

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