Stabilization of a Plasmid Coding for a Heterologous Antigen in Salmonella Enterica Serotype Typhi Vaccine Strain CVD908-htrA by Using Site-specific Recombination

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2006 Jun 23

PMID 16790817

Citations 3

Authors

Jonathan C Stephens

Michael J Darsley

Arthur K Turner

Affiliations

Soon will be listed here.

Abstract

A gene cassette incorporating the crs-rsd site-specific recombination system from the Salmonella enterica subsp. enterica serovar Dublin virulence plasmid improved the inheritance in S. enterica serotype Typhi strain CVD908-htrA of a multicopy plasmid expression vector. Use of this recombination cassette may improve expression of heterologous antigens from multicopy plasmid expression vectors in attenuated bacterial vaccine strains.

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