IgE Sensitisation in Relation to Flow-independent Nitric Oxide Exchange Parameters

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2006 Jun 22

PMID 16787532

Citations 10

Authors

Andrei Malinovschi

Christer Janson

Thomas Holmkvist

Dan Norback

Pekka Merilainen

Marieann Hogman

Affiliations

Soon will be listed here.

Abstract

Background: A positive association between IgE sensitisation and exhaled NO levels has been found in several studies, but there are no reports on the compartment of the lung that is responsible for the increase in exhaled NO levels seen in IgE-sensitised subjects.

Methods: The present study comprised 288 adult subjects from the European Community Respiratory Health Survey II who were investigated in terms of lung function, IgE sensitisation (sum of specific IgE), smoking history and presence of rhinitis and asthma. Mean airway tissue concentration of NO (CawNO), airway transfer factor for NO (DawNO), mean alveolar concentration of NO (CalvNO) and fractional exhaled concentration of NO at a flow rate of 50 mL s(-1) (FENO 0.05) were determined using the extended NO analysis.

Results: IgE-sensitised subjects had higher levels (geometric mean) of FENO 0.05 (24.9 vs. 17.3 ppb) (p < 0.001), DawNO (10.5 vs. 8 mL s(-1)) (p = 0.02) and CawNO (124 vs. 107 ppb) (p < 0.001) and positive correlations were found between the sum of specific IgE and FENO 0.05, CawNO and DawNO levels (p < 0.001 for all correlations). Sensitisation to cat allergen was the major determinant of exhaled NO when adjusting for type of sensitisation. Rhinitis and asthma were not associated with the increase in exhaled NO variables after adjusting for the degree of IgE sensitisation.

Conclusion: The presence of IgE sensitisation and the degree of allergic sensitisation were related to the increase in airway NO transfer factor and the increase in NO concentration in the airway wall. Sensitisation to cat allergen was related to the highest increases in exhaled NO parameters. Our data suggest that exhaled NO is more a specific marker of allergic inflammation than a marker of asthma or rhinitis.

Citing Articles

Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC).

Heffler E, Carpagnano G, Favero E, Guida G, Maniscalco M, Motta A Multidiscip Respir Med. 2020; 15(1):36.

PMID: 32269772 PMC: 7137762. DOI: 10.4081/mrm.2020.36.

FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.

Karimi L, Vijverberg S, Farzan N, Ghanbari M, Verhamme K, Maitland-van der Zee A Clin Exp Allergy. 2019; 49(11):1429-1436.

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New data analysis in a population study raises the hypothesis that particle size contributes to the pro-asthmatic potential of small pet animal allergens.

Patelis A, Dosanjh A, Gunnbjornsdottir M, Borres M, Hogman M, Alving K Ups J Med Sci. 2015; 121(1):25-32.

PMID: 26610050 PMC: 4812054. DOI: 10.3109/03009734.2015.1109569.

House dust mite-specific immunoglobulin E and longitudinal exhaled nitric oxide measurements in children with atopic asthma.

Lee Y, Yang S, Park J, Kim H, Hahn Y Korean J Pediatr. 2015; 58(3):89-95.

PMID: 25861331 PMC: 4388976. DOI: 10.3345/kjp.2015.58.3.89.

Estimation of parameters in the two-compartment model for exhaled nitric oxide.

Eckel S, Linn W, Berhane K, Rappaport E, Salam M, Zhang Y PLoS One. 2014; 9(1):e85471.

PMID: 24465571 PMC: 3894971. DOI: 10.1371/journal.pone.0085471.

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