How to See What You Are Looking for in FMRI and PET--or the Crucial Baseline Condition

Overview

Journal J Neurol

Specialty Neurology

Date 2006 Jun 13

PMID 16767538

Citations 9

Authors

T Brandt

Affiliations

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Abstract

The identification of a baseline or control state is fundamental for the interpretation of task- or stimulation-induced brain activation patterns. The conscious resting state in darkness is a frequently used, but ill-defined mental state. The mere transition from, for example, lid closed to lid open in darkness causes major changes in brain activity,which can mask or mimic a stimulus-dependent brain activation. Contradictory results of seemingly identical brain activation studies may be attributed to the choice of different baseline conditions. Therefore, control conditions that are closest to the stimulus or task condition should be used as baseline in most fMRI and PET studies rather than absolute relaxation in darkness and silence (REST).

Citing Articles

Classification of Resting-State Status Based on Sample Entropy and Power Spectrum of Electroencephalography (EEG).

Mohamed A, Ucan O, Bayat O, Duru A Appl Bionics Biomech. 2020; 2020:8853238.

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The Whole-Brain "Global" Signal from Resting State fMRI as a Potential Biomarker of Quantitative State Changes in Glucose Metabolism.

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Clinical applications of the functional connectome.

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