Functional Magnetic Resonance Imaging for Defining the Biological Target Volume

Overview

Journal Cancer Imaging

Publisher Springer Nature

Specialties Oncology
Radiology

Date 2006 Jun 13

PMID 16766269

Citations 6

Authors

Hans-Ulrich Kauczor

Christian Zechmann

Bram Stieltjes

Marc-Andre Weber

Affiliations

Soon will be listed here.

Abstract

Morphology as demonstrated by CT is the basis for radiotherapy planning. Intensity-modulated and adaptive radiotherapy techniques would greatly benefit from additional functional information allowing for definition of the biological target volume. MRI techniques include several which can characterize and quantify different tissue properties and their tumour-related changes. Results of perfusion MRI represent microvascular density and permeability; MR spectroscopy depicts particular metabolites; diffusion weighted imaging shows tissue at risk and tumour cellularity; while dynamic 3D acquisition (4D MRI) shows organ motion and the mobility of tumours within them.

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References

Stieltjes B, Kaufmann W, van Zijl P, Fredericksen K, Pearlson G, Solaiyappan M . Diffusion tensor imaging and axonal tracking in the human brainstem. Neuroimage. 2001; 14(3):723-35. DOI: 10.1006/nimg.2001.0861. View

Lichy M, Plathow C, Schulz-Ertner D, Kauczor H, Schlemmer H . Follow-up gliomas after radiotherapy: 1H MR spectroscopic imaging for increasing diagnostic accuracy. Neuroradiology. 2005; 47(11):826-34. DOI: 10.1007/s00234-005-1434-0. View

Mori S, Kaufmann W, Davatzikos C, Stieltjes B, Amodei L, Fredericksen K . Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn Reson Med. 2002; 47(2):215-23. DOI: 10.1002/mrm.10074. View

Furman-Haran E, Degani H . Parametric analysis of breast MRI. J Comput Assist Tomogr. 2002; 26(3):376-86. DOI: 10.1097/00004728-200205000-00012. View

Kiessling F, Huber P, Grobholz R, Heilmann M, Meding J, Lichy M . Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapy. Invest Radiol. 2004; 39(1):34-44. DOI: 10.1097/01.rli.0000095472.37056.0b. View

Aoyama H, Kamada K, Shirato H, Takeuchi F, Kuriki S, Iwasaki Y . Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and magnetic resonance axonography. Int J Radiat Oncol Biol Phys. 2004; 58(4):1177-83. DOI: 10.1016/j.ijrobp.2003.08.034. View

Weber M, Thilmann C, Lichy M, Gunther M, Delorme S, Zuna I . Assessment of irradiated brain metastases by means of arterial spin-labeling and dynamic susceptibility-weighted contrast-enhanced perfusion MRI: initial results. Invest Radiol. 2004; 39(5):277-87. DOI: 10.1097/01.rli.0000119195.50515.04. View

Kiessling F, Farhan N, Lichy M, Vosseler S, Heilmann M, Krix M . Dynamic contrast-enhanced magnetic resonance imaging rapidly indicates vessel regression in human squamous cell carcinomas grown in nude mice caused by VEGF receptor 2 blockade with DC101. Neoplasia. 2004; 6(3):213-23. PMC: 1502099. DOI: 10.1593/neo.3394. View

Plathow C, Ley S, Fink C, Puderbach M, Hosch W, Schmahl A . Analysis of intrathoracic tumor mobility during whole breathing cycle by dynamic MRI. Int J Radiat Oncol Biol Phys. 2004; 59(4):952-9. DOI: 10.1016/j.ijrobp.2003.12.035. View

10.

van Dorsten F, van der Graaf M, Engelbrecht M, van Leenders G, Verhofstad A, Rijpkema M . Combined quantitative dynamic contrast-enhanced MR imaging and (1)H MR spectroscopic imaging of human prostate cancer. J Magn Reson Imaging. 2004; 20(2):279-87. DOI: 10.1002/jmri.20113. View

11.

Provenzale J, McGraw P, Mhatre P, Guo A, DeLong D . Peritumoral brain regions in gliomas and meningiomas: investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging. Radiology. 2004; 232(2):451-60. DOI: 10.1148/radiol.2322030959. View

12.

Wasser K, Moehler T, Neben K, Nosas S, Heiss J, Goldschmidt H . [Dynamic MRI of the bone marrow for monitoring multiple myeloma during treatment with thalidomide as monotherapy or in combination with CED chemotherapy]. Rofo. 2004; 176(9):1285-95. DOI: 10.1055/s-2004-813414. View

13.

Plathow C, Fink C, Ley S, Puderbach M, Eichinger M, Zuna I . Measurement of tumor diameter-dependent mobility of lung tumors by dynamic MRI. Radiother Oncol. 2004; 73(3):349-54. DOI: 10.1016/j.radonc.2004.07.017. View

14.

Plathow C, Zimmermann H, Fink C, Umathum R, Schobinger M, Huber P . Influence of different breathing maneuvers on internal and external organ motion: use of fiducial markers in dynamic MRI. Int J Radiat Oncol Biol Phys. 2005; 62(1):238-45. DOI: 10.1016/j.ijrobp.2005.01.042. View

15.

Giraud P, De Rycke Y, Dubray B, Helfre S, Voican D, Guo L . Conformal radiotherapy (CRT) planning for lung cancer: analysis of intrathoracic organ motion during extreme phases of breathing. Int J Radiat Oncol Biol Phys. 2001; 51(4):1081-92. DOI: 10.1016/s0360-3016(01)01766-7. View