Characterization of VP1, VP2 and VP3 Gene Segments of a Human Rotavirus Closely Related to Porcine Strains

Overview

Journal Virus Genes

Specialties Microbiology
Molecular Biology

Date 2006 May 30

PMID 16732476

Citations 11

Authors

Vici Varghese

Souvik Ghosh

Soma Das

Sujit Kumar Bhattacharya

Triveni Krishnan

Parimal Karmakar

Nobumichi Kobayashi

Trailokya Nath Naik

Affiliations

Soon will be listed here.

Abstract

Long RNA electropherotype rotavirus strains with subgroup I specificity predominated the infantile gastroenteritis outbreak in Manipur, India, in 1987-88. One such strain (RMC321) was found to possess porcine characteristics in 7 out of 8 genes sequenced. Partial characterization of its remaining VP1, VP2 and VP3 genes along with a porcine rotavirus strain (HP140) uncovered their close genetic relation to porcine strains. VP7 was the only gene segment of this strain with significant genetic identity to human strains. This indicates that a rotavirus reassortant strain with most of its genetic material derived from a porcine strain may cause symptomatic infection in a human host.

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