Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2006 May 30

PMID 16731944

Citations 33

Authors

Aleksandr Lazaryan

Elena Lobashevsky

Joseph Mulenga

Etienne Karita

Susan Allen

Jianming Tang

Richard A Kaslow

Affiliations

Soon will be listed here.

Abstract

Human leukocyte antigen (HLA) class I alleles can be grouped into supertypes according to their shared peptide binding properties. We examined alleles of the HLA-B58 supertype (B58s) in treatment-naïve human immunodeficiency virus type 1 (HIV-1)-seropositive Africans (423 Zambians and 202 Rwandans). HLA-B and HLA-C alleles were resolved to four digits by a combination of molecular methods, and their respective associations with outcomes of HIV-1 infection were analyzed by statistical procedures appropriate for continuous or categorical data. The effects of the individual alleles on natural HIV-1 infection were heterogeneous. In HIV-1 subtype C-infected Zambians, the mean viral load (VL) was lower among B*5703 (P = 0.01) or B*5703-Cw*18 (P < 0.001) haplotype carriers and higher among B*5802 (P = 0.02) or B*5802-Cw*0602 (P = 0.03) carriers. The B*5801-Cw*03 haplotype showed an association with low VL (P = 0.05), whereas B*5801 as a whole did not. Rwandans with HIV-1 subtype A infection showed associations of B*5703 and B*5802 with slow (P = 0.06) and rapid (P = 0.003) disease progression, respectively. In neither population were B*1516-B*1517 alleles associated with more favorable responses. Overall, B58s alleles, individually or as part of an HLA-B-HLA-C haplotype, appeared to have a distinctive impact on HIV-1 infection among native Africans. As presently defined, B58s alleles cannot be considered uniformly protective against HIV/AIDS in every population.

Citing Articles

Exome Sequencing Reveals a Putative Role for HLA-C*03:02 in Control of HIV-1 in African Pediatric Populations.

Kyobe S, Mwesigwa S, Kisitu G, Farirai J, Katagirya E, Mirembe A Front Genet. 2021; 12:720213.

PMID: 34512729 PMC: 8428176. DOI: 10.3389/fgene.2021.720213.

HLA class-I-peptide stability mediates CD8 T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.

Kaseke C, Park R, Singh N, Koundakjian D, Bashirova A, Garcia Beltran W Cell Rep. 2021; 36(2):109378.

PMID: 34260940 PMC: 8293625. DOI: 10.1016/j.celrep.2021.109378.

Immunogenetic determinants of heterosexual HIV-1 transmission: key findings and lessons from two distinct African cohorts.

Tang J Genes Immun. 2021; 22(2):65-74.

PMID: 33934119 PMC: 8225584. DOI: 10.1038/s41435-021-00130-y.

Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes.

Camacho-Bydume C, Wang T, Sees J, Fernandez-Vina M, Abid M, Askar M Transplant Cell Ther. 2020; 27(2):142.e1-142.e11.

PMID: 33053450 PMC: 8015676. DOI: 10.1016/j.bbmt.2020.10.010.

Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.

Valenzuela-Ponce H, Alva-Hernandez S, Garrido-Rodriguez D, Soto-Nava M, Garcia-Tellez T, Escamilla-Gomez T Sci Rep. 2018; 8(1):6111.

PMID: 29666450 PMC: 5904102. DOI: 10.1038/s41598-018-23849-7.

References

Scherer A, Frater J, Oxenius A, Agudelo J, Price D, Gunthard H . Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. Proc Natl Acad Sci U S A. 2004; 101(33):12266-70. PMC: 514467. DOI: 10.1073/pnas.0404091101. View

Reche P, Reinherz E . Definition of MHC supertypes through clustering of MHC peptide-binding repertoires. Methods Mol Biol. 2008; 409:163-73. DOI: 10.1007/978-1-60327-118-9_11. View

Kiepiela P, Leslie A, Honeyborne I, Ramduth D, Thobakgale C, Chetty S . Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004; 432(7018):769-75. DOI: 10.1038/nature03113. View

Longmate J, York J, La Rosa C, Krishnan R, Zhang M, Senitzer D . Population coverage by HLA class-I restricted cytotoxic T-lymphocyte epitopes. Immunogenetics. 2001; 52(3-4):165-73. DOI: 10.1007/s002510000271. View

Haynes B . HIV vaccines: where we are and where we are going. Lancet. 1996; 348(9032):933-7. DOI: 10.1016/S0140-6736(96)09339-7. View

Stewart-Jones G, Gillespie G, Overton I, Kaul R, Roche P, McMichael A . Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression. J Immunol. 2005; 175(4):2459-68. DOI: 10.4049/jimmunol.175.4.2459. View

Frahm N, Adams S, Kiepiela P, Linde C, Hewitt H, Lichterfeld M . HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. J Virol. 2005; 79(16):10218-25. PMC: 1182636. DOI: 10.1128/JVI.79.16.10218-10225.2005. View

Trachtenberg E, Korber B, Sollars C, Kepler T, Hraber P, Hayes E . Advantage of rare HLA supertype in HIV disease progression. Nat Med. 2003; 9(7):928-35. DOI: 10.1038/nm893. View

McKenna S, Muyinda G, Roth D, Mwali M, Ngandu N, Myrick A . Rapid HIV testing and counseling for voluntary testing centers in Africa. AIDS. 1997; 11 Suppl 1:S103-10. View

10.

Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G . Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. J Virol. 2002; 76(16):8276-84. PMC: 155130. DOI: 10.1128/jvi.76.16.8276-8284.2002. View

11.

Sette A, Sidney J . HLA supertypes and supermotifs: a functional perspective on HLA polymorphism. Curr Opin Immunol. 1998; 10(4):478-82. DOI: 10.1016/s0952-7915(98)80124-6. View

12.

Tang J, Tang S, Lobashevsky E, Zulu I, Aldrovandi G, Allen S . HLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partners. AIDS Res Hum Retroviruses. 2004; 20(1):19-25. DOI: 10.1089/088922204322749468. View

13.

Zeger S, Liang K . Longitudinal data analysis for discrete and continuous outcomes. Biometrics. 1986; 42(1):121-30. View

14.

Dorak M, Tang J, Penman-Aguilar A, Westfall A, Zulu I, Lobashevsky E . Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples. Lancet. 2004; 363(9427):2137-9. DOI: 10.1016/S0140-6736(04)16505-7. View

15.

Martin M, Gao X, Lee J, Nelson G, Detels R, Goedert J . Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002; 31(4):429-34. DOI: 10.1038/ng934. View

16.

Tang J, Costello C, Keet I, Rivers C, Leblanc S, Karita E . HLA class I homozygosity accelerates disease progression in human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 1999; 15(4):317-24. DOI: 10.1089/088922299311277. View

17.

Novitsky V, Gilbert P, Peter T, McLane M, Gaolekwe S, Rybak N . Association between virus-specific T-cell responses and plasma viral load in human immunodeficiency virus type 1 subtype C infection. J Virol. 2002; 77(2):882-90. PMC: 140844. DOI: 10.1128/jvi.77.2.882-890.2003. View

18.

Costello C, Tang J, Rivers C, Karita E, Allen S, Kaslow R . HLA-B*5703 independently associated with slower HIV-1 disease progression in Rwandan women. AIDS. 1999; 13(14):1990-1. DOI: 10.1097/00002030-199910010-00031. View

19.

Bello G, Casado C, Sandonis V, Alonso-Nieto M, Vicario J, Garcia S . A subset of human immunodeficiency virus type 1 long-term non-progressors is characterized by the unique presence of ancestral sequences in the viral population. J Gen Virol. 2005; 86(Pt 2):355-364. DOI: 10.1099/vir.0.80410-0. View

20.

Novitsky V, Rybak N, McLane M, Gilbert P, Chigwedere P, Klein I . Identification of human immunodeficiency virus type 1 subtype C Gag-, Tat-, Rev-, and Nef-specific elispot-based cytotoxic T-lymphocyte responses for AIDS vaccine design. J Virol. 2001; 75(19):9210-28. PMC: 114489. DOI: 10.1128/JVI.75.19.9210-9228.2001. View