Quantifiable Cytotoxic T Lymphocyte Responses and HLA-related Risk of Progression to AIDS

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2004 Aug 11

PMID 15302942

Citations 40

Authors

Almut Scherer

John Frater

Annette Oxenius

Juliet Agudelo

David A Price

Huldrych F Gunthard

Martin Barnardo

Luc Perrin

Bernard Hirschel

Rodney E Phillips

Angela R McLean

Affiliations

Soon will be listed here.

Abstract

There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory mechanism for this relationship. Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV.

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