» Articles » PMID: 16723979

Chromatin Remodelling: the Industrial Revolution of DNA Around Histones

Overview
Date 2006 May 26
PMID 16723979
Citations 271
Authors
Affiliations
Soon will be listed here.
Abstract

Chromatin remodellers are specialized multi-protein machines that enable access to nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All remodellers have a catalytic ATPase subunit that is similar to known DNA-translocating motor proteins, suggesting DNA translocation as a unifying aspect of their mechanism. Here, we explore the diversity and specialization of chromatin remodellers, discuss how nucleosome modifications regulate remodeller activity and consider a model for the exposure of nucleosomal DNA that involves the use of directional DNA translocation to pump 'DNA waves' around the nucleosome.

Citing Articles

The Impact of Epigenetics on the Pathophysiology of Type 2 Diabetes and Associated Nephropathic Complications.

Mukherjee A, Debbarman T, Banerjee B, Siddiqi S Indian J Endocrinol Metab. 2025; 28(6):569-578.

PMID: 39881775 PMC: 11774419. DOI: 10.4103/ijem.ijem_43_24.


Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors.

Mironova E, Molinas S, Pozo V, Bandyopadhyay A, Lai Z, Kurmashev D Cancers (Basel). 2024; 16(11).

PMID: 38893160 PMC: 11171327. DOI: 10.3390/cancers16112041.


Acute depletion of BRG1 reveals its primary function as an activator of transcription.

Ren G, Ku W, Ge G, Hoffman J, Kang J, Tang Q Nat Commun. 2024; 15(1):4561.

PMID: 38811575 PMC: 11137027. DOI: 10.1038/s41467-024-48911-z.


Epigenetic regulation in cancer.

Gu M, Ren B, Fang Y, Ren J, Liu X, Wang X MedComm (2020). 2024; 5(2):e495.

PMID: 38374872 PMC: 10876210. DOI: 10.1002/mco2.495.


Research progress of SWI/SNF complex in breast cancer.

Li K, Wang B, Hu H Epigenetics Chromatin. 2024; 17(1):4.

PMID: 38365747 PMC: 10873968. DOI: 10.1186/s13072-024-00531-z.