Impact of Opportunistic Mycobacterium Tuberculosis Infection on the Phenotype of Peripheral Blood T Cells of AIDS Patients

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2006 May 25

PMID 16721821

Citations 3

Authors

German Bernal-Fernandez

Carlos Hermida

Patricia Espinosa-Cueto

Ana Cristina Cubilla-Tejeda

Jesus Fidel Salazar-Gonzalez

Librado Ortiz-Ortiz

Rosario Leyva-Meza

Hugo Diaz-Silvestre

Raul Mancilla

Affiliations

Soon will be listed here.

Abstract

While the detrimental consequences of opportunistic tuberculosis (TB) in the course and outcome of HIV-1 infection are well studied, little information about the impact of the mycobacterial infection on the phenotype of T lymphocytes is available. In this study we analyzed by cytofluorimetry the peripheral blood T cell phenotype of 13 patients with AIDS, 23 HIV-1 negative patients with active pulmonary TB, nine HIV-1/Mycobacterium tuberculosis coinfected individuals, and 21 age- and sex-matched healthy controls. CD4+ T cells were equally depleted in AIDS and coinfection (P<0.001). The findings suggest a rescuing effect of the added mycobacterial infection. CD3 T cell loss was not observed in coinfection, whereas it was severe in AIDS (P<0.001). Similar (albeit less striking) effects were observed with other markers (CD45RA, CD45RO, and CD27) that were diminished in CD4+ T cells of AIDS patients. Apparent detrimental effects of the added mycobacterial infection were the increased expression of the proapoptotic molecule CD95 on CD4+ T cells, and decreased expression of the major costimulatory molecule CD28 on CD8+ T cells. In this work we show that M. tuberculosis infection modifies the T cell phenotype of the HIV-1 infected individual.

Citing Articles

HIV Productively Infects Highly Differentiated and Exhausted CD4+ T Cells During AIDS.

Faua C, Ursenbach A, Fuchs A, Caspar S, Jegou F, Ruch Y Pathog Immun. 2024; 8(2):92-114.

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Is analysis of inflammatory biomarkers and lymphocyte subpopulations useful in prediction of tuberculosis treatment outcomes?.

Musteikiene G, Miliauskas S, Zaveckiene J, Urboniene D, Vitkauskiene A, Zemaitis M J Clin Tuberc Other Mycobact Dis. 2021; 25:100275.

PMID: 34541339 PMC: 8436121. DOI: 10.1016/j.jctube.2021.100275.

Decreased expression of T-cell costimulatory molecule CD28 on CD4 and CD8 T cells of mexican patients with pulmonary tuberculosis.

Bernal-Fernandez G, Espinosa-Cueto P, Leyva-Meza R, Mancilla N, Mancilla R Tuberc Res Treat. 2012; 2010:517547.

PMID: 22567259 PMC: 3335659. DOI: 10.1155/2010/517547.

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