Expression of B7 (CD80) and CD40 Antigens and the CD40 Ligand in Hodgkin's Disease is Independent of Latent Epstein-Barr Virus Infection

Overview

Journal Clin Mol Pathol

Specialty Molecular Biology

Date 1995 Apr 1

PMID 16695980

Citations 2

Authors

P G Murray

J Oates

G M Reynolds

J Crocker

L S Young

Affiliations

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Abstract

Aim-To examine the expression of CD40 and B7 (CD80) antigens and the CD40 ligand in Hodgkin's disease.Methods-Antigen and ligand expression was studied in 17 cases of Hodgkin's disease using immunohistochemistry. The study included 11 cases of Hodgkin's disease in which latent Epstein-Barr virus (EBV) infection could be demonstrated within tumour cells by in situ hybridisation for the EBV encoded early RNAs (EBERs).Results-In all cases, irrespective of EBV status, Reed-Sternberg cells and their variants (HRS cells) showed strong expression of both B7 and CD40 antigens. CD40 ligand expression was not shown in HRS cells but was confined to a subset of small lymphocytes some of which were seen to be in intimate contact with HRS cells.Paraffin wax sections from a further 60 cases of Hodgkin's disease were examined for CD40 and EBER expression alone. The CD40 antigen was identified in HRS cells in all of these cases irrespective of EBER expression.Conclusions-As CD40 and B7 expression are features of professional antigen presenting cells, these results provide further evidence that HRS cells may have antigen presenting properties and that this may contribute to the characteristic recruitment and activation of non-malignant lymphocytes which is a feature of Hodgkin's disease. The ability of HRS cells to activate T(h) cells may in turn contribute to their own survival through the induction of the gp39/CD40 pathway.

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References

Griesser H, Feller A, Mak T, Lennert K . Clonal rearrangements of T-cell receptor and immunoglobulin genes and immunophenotypic antigen expression in different subclasses of Hodgkin's disease. Int J Cancer. 1987; 40(2):157-60. DOI: 10.1002/ijc.2910400205. View

Kadin M, Stites D, Levy R, Warnke R . Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin's disease. N Engl J Med. 1978; 299(22):1208-14. DOI: 10.1056/NEJM197811302992203. View

Thompson C, LINDSTEN T, Ledbetter J, Kunkel S, Young H, Emerson S . CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A. 1989; 86(4):1333-7. PMC: 286684. DOI: 10.1073/pnas.86.4.1333. View

Angel C, Pringle J, Naylor J, West K, LAUDER I . Analysis of antigen receptor genes in Hodgkin's disease. J Clin Pathol. 1993; 46(4):337-40. PMC: 501215. DOI: 10.1136/jcp.46.4.337. View

Linsley P, Clark E, Ledbetter J . T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A. 1990; 87(13):5031-5. PMC: 54255. DOI: 10.1073/pnas.87.13.5031. View

Lee S, Thomas W, Murray R, Khanim F, Kaur S, Young L . HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2. J Virol. 1993; 67(12):7428-35. PMC: 238208. DOI: 10.1128/JVI.67.12.7428-7435.1993. View

Fisher R, Sauder D, Scala G, Diehl V . Neoplastic cells obtained from Hodgkin's disease are potent stimulators of human primary mixed lymphocyte cultures. J Immunol. 1983; 130(6):2666-70. View

Uchiyama T, Nelson D, Fleisher T, Waldmann T . A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells. J Immunol. 1981; 126(4):1398-403. View

STEIN H, Mason D, Gerdes J, OConnor N, Wainscoat J, Pallesen G . The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985; 66(4):848-58. View

10.

Fisher R, Cossman J, Diehl V, Volkman D . Antigen presentation by Hodgkin's disease cells. J Immunol. 1985; 135(5):3568-71. View

11.

Ranheim E, Kipps T . Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med. 1993; 177(4):925-35. PMC: 2190967. DOI: 10.1084/jem.177.4.925. View

12.

Gimmi C, Freeman G, Gribben J, Sugita K, Freedman A, Morimoto C . B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A. 1991; 88(15):6575-9. PMC: 52129. DOI: 10.1073/pnas.88.15.6575. View

13.

Pallesen G, Hamilton-Dutoit S, Rowe M, Young L . Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet. 1991; 337(8737):320-2. DOI: 10.1016/0140-6736(91)90943-j. View

14.

Spriggs M, Armitage R, Strockbine L, Clifford K, Macduff B, Sato T . Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med. 1992; 176(6):1543-50. PMC: 2119450. DOI: 10.1084/jem.176.6.1543. View

15.

Delabie J, Ceuppens J, Vandenberghe P, de Boer M, Coorevits L, De Wolf-Peeters C . The B7/BB1 antigen is expressed by Reed-Sternberg cells of Hodgkin's disease and contributes to the stimulating capacity of Hodgkin's disease-derived cell lines. Blood. 1993; 82(9):2845-52. View

16.

Delsol G, Meggetto F, Brousset P, Al Saati T, Rochaix P, Gorguet B . Relation of follicular dendritic reticulum cells to Reed-Sternberg cells of Hodgkin's disease with emphasis on the expression of CD21 antigen. Am J Pathol. 1993; 142(6):1729-38. PMC: 1886971. View

17.

Curran R, Jones E . Dendritic cells and B lymphocytes in Hodgkin's disease. Lancet. 1977; 2(8033):349. DOI: 10.1016/s0140-6736(77)91502-1. View

18.

Soderstrom K, Rinne R, Hopsu-Havu V, Jarvinen M, Rinne A . Hodgkin's disease: a malignancy of follicular dendritic cells?. Lancet. 1994; 343(8894):422-3. DOI: 10.1016/s0140-6736(94)91260-2. View

19.

Armitage R, Fanslow W, Strockbine L, Sato T, Clifford K, Macduff B . Molecular and biological characterization of a murine ligand for CD40. Nature. 1992; 357(6373):80-2. DOI: 10.1038/357080a0. View

20.

Barletta J, Kingma D, Ling Y, CHARACHE P, Mann R, Ambinder R . Rapid in situ hybridization for the diagnosis of latent Epstein-Barr virus infection. Mol Cell Probes. 1993; 7(2):105-9. DOI: 10.1006/mcpr.1993.1014. View