THE "INDUCTION" OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1963 Apr 1

PMID 16695899

Citations 15

Authors

J R Bertino

D M Donohue

B Simmons

B W GABRIO

R Silber

F M Huennekens

Affiliations

Soon will be listed here.

Citing Articles

From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.

Walling J Invest New Drugs. 2005; 24(1):37-77.

PMID: 16380836 DOI: 10.1007/s10637-005-4541-1.

STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE.

Bertino J, Silber R, Freeman M, ALENTY A, Albrecht M, GABRIO B J Clin Invest. 1963; 42:1899-907.

PMID: 14090749 PMC: 289477. DOI: 10.1172/JCI104875.

Determinants of trimetrexate lethality in human colon cancer cells.

Grem J, Voeller D, Geoffroy F, Horak E, Johnston P, Allegra C Br J Cancer. 1994; 70(6):1075-84.

PMID: 7981057 PMC: 2033700. DOI: 10.1038/bjc.1994.451.

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

Varshavsky A Proc Natl Acad Sci U S A. 1981; 78(6):3673-7.

PMID: 6943571 PMC: 319633. DOI: 10.1073/pnas.78.6.3673.

Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.

Robertson S, Ling V, Stanners C Mol Cell Biol. 1984; 4(3):500-6.

PMID: 6144041 PMC: 368728. DOI: 10.1128/mcb.4.3.500-506.1984.

References

OTTESEN J . On the age of human white cells in peripheral blood. Acta Physiol Scand. 1954; 32(1):75-93. DOI: 10.1111/j.1748-1716.1954.tb01157.x. View

FUTTERMAN S, Silverman M . The inactivation of folic acid by liver. J Biol Chem. 1957; 224(1):31-40. View

Huennekens F, CAFFREY R, Basford R, GABRIO B . Erythrocyte metabolism. IV. Isolation and properties of methemoglobin reductase. J Biol Chem. 1957; 227(1):261-72. View

HENNESSEY M, WALTERSDORPH A, Huennekens F, GABRIO B . Erythrocyte metabolism. VI. Separation of erythrocyte enzymes from hemoglobin. J Clin Invest. 1962; 41:1257-62. PMC: 291040. DOI: 10.1172/JCI104588. View

Moyed H . Interference with the feed-back control of histidine biosynthesis. J Biol Chem. 1961; 236:2261-7. View

Huennekens F, Osborn M, WHITELEY H . Folic acid coenzymes. Science. 1958; 128(3316):120-4. DOI: 10.1126/science.128.3316.120. View

CRADDOCK C, NAKAI G . Leukemic cell proliferation as determined by in vitro deoxyribonucleic acid synthesis. J Clin Invest. 1962; 41:360-9. PMC: 289234. DOI: 10.1172/JCI104490. View

ANTON A, Nichol C . Studies on the nature of resistance of Streptococcus faecalis to folic acid antagonists. Biochem Pharmacol. 1959; 3:1-9. DOI: 10.1016/0006-2952(59)90002-4. View

ZAKRZEWSKI S, Nichol C . Evidence for a single enzyme reducing folate and dihydrofolate. J Biol Chem. 1960; 235:2984-8. View

10.

Fischer G . Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells. Biochem Pharmacol. 1961; 7:75-7. DOI: 10.1016/0006-2952(61)90128-9. View

11.

ZAKRZEWSKI S, Nichol C . On the enzymic reduction of folic acid by a purified hydrogenase. Biochim Biophys Acta. 1958; 27(2):425-6. DOI: 10.1016/0006-3002(58)90360-3. View

12.

Bertino J, Simmons B, Donohue D . Purification and properties of the formate-activating enzyme from erythrocytes. J Biol Chem. 1962; 237:1314-8. View

13.

HAKALA M, ZAKRZEWSKI S, Nichol C . Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells. J Biol Chem. 1961; 236:952-8. View

14.

Nichol C, ZAKRZEWSKI S, WELCH A . Resistance to folic acid analogues in a strain of Streptococcus faecalis. Proc Soc Exp Biol Med. 1953; 83(2):272-7. DOI: 10.3181/00379727-83-20332. View

15.

Bertino J, DONOHUE D, GABRIO B, Silber R, ALENTY A, Meyer M . Increased level of dihydrofolic reductase in leucocytes of patients treated with amethopterin. Nature. 1962; 193:140-2. DOI: 10.1038/193140a0. View

16.

Nichol C, WELCH A . On the mechanism of action of aminopterin. Proc Soc Exp Biol Med. 1950; 74(2):403-11. DOI: 10.3181/00379727-74-17922. View

17.

BROQUIST H, Kohler A, Hutchison D, Burchenal J . Studies on the enzymatic formation of citrovorum factor by Streptococcus faecalis. J Biol Chem. 1953; 202(1):59-66. View

18.

Misra D, HUMPHREYS S, FRIEDKIN M, Goldin A, CRAWFORD E . Increased dihydrofolate reductase activity as a possible basis of drug resistance in leukaemia. Nature. 1961; 189:39-42. DOI: 10.1038/189039a0. View

19.

Osborn M, Huennekens F . Enzymatic reduction of dihydrofolic acid. J Biol Chem. 1958; 233(4):969-74. View

20.

FUTTERMAN S . Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid. J Biol Chem. 1957; 228(2):1031-8. View