The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors

Overview

Journal Drug Metab Rev

Publisher Informa Healthcare

Specialty Pharmacology

Date 2006 May 11

PMID 16684650

Citations 62

Authors

Stephanie J Webb

Thomas E Geoghegan

Russell A Prough

Kristy K Michael Miller

Affiliations

Soon will be listed here.

Abstract

Dehydroepiandrosterone has been thought to have physiological functions other than as an androgen precursor. The previous studies performed have demonstrated a number of biological effects in rodents, such as amelioration of disease in diabetic, chemical carcinogenesis, and obesity models. To date, activation of the peroxisome proliferators activated receptor alpha, pregnane X receptor, and estrogen receptor by DHEA and its metabolites have been demonstrated. Several membrane-associated receptors have also been elucidated leading to additional mechanisms by which DHEA may exert its biological effects. This review will provide an overview of the receptor multiplicity involved in the biological activity of this sterol.

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