Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease After Allogeneic Stem Cell Transplantation

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2006 May 5

PMID 16672419

Citations 20

Authors

Juergen Loeffler

Michael Steffens

Eva-Maria Arlt

Mohammad-Reza Toliat

Markus Mezger

Anita Suk

Thomas F Wienker

Holger Hebart

Peter Nurnberg

Michael Boeckh

Per Ljungman

Rudolf Trenschel

Hermann Einsele

Affiliations

Soon will be listed here.

Abstract

We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.

Citing Articles

Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study.

Bodro M, Cervera C, Linares L, Suarez B, Llopis J, Sanclemente G Front Immunol. 2022; 13:897912.

PMID: 36016941 PMC: 9397545. DOI: 10.3389/fimmu.2022.897912.

Risk prediction of CMV reactivation after allogeneic stem cell transplantation using five non-HLA immunogenetic polymorphisms.

Vallejo M, Muniz P, Kwon M, Solan L, Bailen R, Carbonell D Ann Hematol. 2022; 101(7):1567-1576.

PMID: 35525883 PMC: 9203380. DOI: 10.1007/s00277-022-04841-8.

Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection.

Czech-Kowalska J, Jedlinska-Pijanowska D, Pleskaczynska A, Niezgoda A, Gradowska K, Pietrzyk A Viruses. 2021; 13(9).

PMID: 34578364 PMC: 8473223. DOI: 10.3390/v13091783.

Genetic variants associated with cytomegalovirus infection after allogeneic hematopoietic cell transplantation.

Casto A, Seo S, Levine D, Storer B, Dong X, Hansen J Blood. 2021; 138(17):1628-1636.

PMID: 34269803 PMC: 8554648. DOI: 10.1182/blood.2021012153.

No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection-Subanalysis of the prospective randomised VIPP study.

Mazzola P, Schaeffeler E, Witzke O, Nitschke M, Kliem V, Zortel M PLoS One. 2021; 16(4):e0246118.

PMID: 33861738 PMC: 8051780. DOI: 10.1371/journal.pone.0246118.

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