Direct Asymmetric Hydroxyamination Reaction Catalyzed by an Axially Chiral Secondary Amine Catalyst
Overview
Affiliations
A direct asymmetric hydroxyamination reaction of aldehydes with nitrosobenzene was found to be catalyzed by the novel axially chiral secondary amine catalyst (S)-1d. The resulting optically enriched hydroxyamination products were readily converted to beta-amino alcohols or 1,2-diamines in one pot.
Enantioselective organocatalytic strategies to access noncanonical α-amino acids.
Pecchini P, Fochi M, Bartoccini F, Piersanti G, Bernardi L Chem Sci. 2024; 15(16):5832-5868.
PMID: 38665517 PMC: 11041364. DOI: 10.1039/d4sc01081g.
Organocatalytic Enantioselective α-Bromination of Aldehydes with -Bromosuccinimide.
Hutchinson G, Alamillo-Ferrer C, Fernandez-Pascual M, Bures J J Org Chem. 2022; 87(12):7968-7974.
PMID: 35617931 PMC: 9207931. DOI: 10.1021/acs.joc.2c00600.
Organocatalytic asymmetric nitroso aldol reaction of αsubstituted malonamates.
Gupta E, Vaishanv N, Kumar S, Purshottam R, Kant R, Mohanan K Beilstein J Org Chem. 2022; 18:217-224.
PMID: 35280951 PMC: 8895028. DOI: 10.3762/bjoc.18.25.
Enhancing the selectivity of prolinamide organocatalysts using the mechanical bond in [2]rotaxanes.
Calles M, Puigcerver J, Alonso D, Alajarin M, Martinez-Cuezva A, Berna J Chem Sci. 2021; 11(14):3629-3635.
PMID: 34094051 PMC: 8152698. DOI: 10.1039/d0sc00444h.
Yeung C, Chan W, Lo W, Law G, Wong W Molecules. 2019; 24(3).
PMID: 30759758 PMC: 6385101. DOI: 10.3390/molecules24030643.