Efficacy of Chloramphenicol, Enrofloxacin, and Tetracycline for Treatment of Experimental Rocky Mountain Spotted Fever in Dogs

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1991 Nov 1

PMID 1666498

Citations 10

Authors

E B Breitschwerdt

M G Davidson

D P Aucoin

M G Levy

N S Szabados

B C Hegarty

A L Kuehne

R L James

Affiliations

Soon will be listed here.

Abstract

Dogs were experimentally inoculated with Rickettsia rickettsii to characterize the comparative efficacies of chloramphenicol, enrofloxacin, and tetracycline for the treatment of Rocky Mountain spotted fever (RMSF). All three antibiotics were equally effective in abrogating the clinical, hematologic, and vascular indicators of rickettsial infection. Antibiotic treatment for 24 h was sufficient to decrease the rickettsemia to levels below detection by Vero cell culture. Early treatment with all three antibiotics resulted in a similar decrease in antibody titer, but acute and convalescent serum samples taken at appropriate times would have still facilitated an accurate diagnosis of RMSF in all but one dog, which did not seroconvert. We conclude that chloramphenicol, enrofloxacin, and tetracycline are equally efficacious for treating experimental canine RMSF.

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