Iron Loading: a Risk Factor for Osteoporosis

Overview

Journal Biometals

Specialty Biochemistry

Date 2006 May 2

PMID 16648989

Citations 28

Authors

E D Weinberg

Affiliations

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Abstract

Iron loaded persons are at increased risk for infection, neoplasia, arthropathy, cardiomyopathy and an array of endocrine and neurodegenerative diseases. This report summarizes evidence of increased risk of iron loading for osteoporosis. Iron suppresses bone remodeling apparently by decreasing osteoblast formation and new bone synthesis. Low molecular mass iron chelators as well as a natural protein iron chelator, lactoferrin, may be useful in prevention of osteoporosis.

Citing Articles

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Iron accumulation deteriorated bone loss in estrogen-deficient rats.

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