Neural Stem Cells and Their Role in Recovery Processes in the Nervous System

Overview

Journal Neurosci Behav Physiol

Publisher Springer

Date 2006 Apr 29

PMID 16645765

Citations 2

Authors

L I Korochkin

A V Revishchin

V E Okhotin

Affiliations

Soon will be listed here.

Abstract

Published data and our own results on the identification, cultivation, and potential therapeutic utilization of regional stem cells from humans and animals are reviewed. Pluripotent stem cells have been shown to proliferate in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampal formation in adult human and animal brains. Data on the hierarchical organization of genetic networks in controlling individual development suggest a possible functional role for repeat mini-and microsatellite DNA sequences in stem cell differentiation. Methods of using human bone marrow as a source of stem cells for restoring damaged tissue in the brain are discussed. Heat-shock proteins have been found to block the formation of glial scars after neural transplantation. The viability of stem cells after transplantation can be increased by transfer of genes for neurotrophic growth factors into the genomes of the neurons undergoing transplantation.

Citing Articles

Stem cells and neuroprotection: understanding the players.

Pearce V Int J Mol Sci. 2010; 11(9):3288-97.

PMID: 20957094 PMC: 2956095. DOI: 10.3390/ijms11093288.

Neural progenitor cells grown on hydrogel surfaces respond to the product of the transgene of encapsulated genetically engineered fibroblasts.

Shanbhag M, Lathia J, Mughal M, Francis N, Pashos N, Mattson M Biomacromolecules. 2010; 11(11):2936-43.

PMID: 20942395 PMC: 3775902. DOI: 10.1021/bm100699q.

References

Mezey E, Key S, Vogelsang G, Szalayova I, Lange G, Crain B . Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A. 2003; 100(3):1364-9. PMC: 298778. DOI: 10.1073/pnas.0336479100. View

Altman J, Das G . Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol. 1965; 124(3):319-35. DOI: 10.1002/cne.901240303. View

Doetsch F, Alvarez-Buylla A . Network of tangential pathways for neuronal migration in adult mammalian brain. Proc Natl Acad Sci U S A. 1996; 93(25):14895-900. PMC: 26233. DOI: 10.1073/pnas.93.25.14895. View

Reynolds B, Weiss S . Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992; 255(5052):1707-10. DOI: 10.1126/science.1553558. View

Castro R, Jackson K, Goodell M, Robertson C, Liu H, Shine H . Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science. 2002; 297(5585):1299. DOI: 10.1126/science.297.5585.1299. View

Suhonen J, Peterson D, Ray J, Gage F . Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature. 1996; 383(6601):624-7. DOI: 10.1038/383624a0. View

Soares S, Sotelo C . Adult neural stem cells from the mouse subventricular zone are limited in migratory ability compared to progenitor cells of similar origin. Neuroscience. 2004; 128(4):807-17. DOI: 10.1016/j.neuroscience.2004.07.031. View

Korochkin L . [Stem cells]. Ontogenez. 2003; 34(3):164-6. View

Poltavtseva R, Marey M, Aleksandrova M, Revishchin A, Korochkin L, Sukhikh G . Evaluation of progenitor cell cultures from human embryos for neurotransplantation. Brain Res Dev Brain Res. 2002; 134(1-2):149-54. DOI: 10.1016/s0165-3806(02)00274-2. View

10.

Palmer T, Markakis E, Willhoite A, Safar F, Gage F . Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci. 1999; 19(19):8487-97. PMC: 6783019. View

11.

Hofstetter C, Schwarz E, Hess D, Widenfalk J, El Manira A, Prockop D . Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A. 2002; 99(4):2199-204. PMC: 122342. DOI: 10.1073/pnas.042678299. View

12.

Shchegelskaia E, Mikulinskii I, Revishchin A, Omelchenko E, Kulshin V, Grishchenko V . [Pluripotency of bone marrow stromal cells and perspectives of their use in cell therapy]. Ontogenez. 2003; 34(3):228-35. View

13.

Snyder E, Yoon C, Flax J, Macklis J . Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc Natl Acad Sci U S A. 1997; 94(21):11663-8. PMC: 23575. DOI: 10.1073/pnas.94.21.11663. View

14.

Aleksandrova M, Revishchin A, Poltavtseva R, Cherkasova L, Kleshchinov V, Korochkin L . [Transplantation of stem/progenitor cells of human brain into the brain of adult rats]. Ontogenez. 2003; 34(3):167-73. View

15.

Woodbury D, Schwarz E, Prockop D, Black I . Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 2000; 61(4):364-70. DOI: 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C. View

16.

Noctor S, Flint A, Weissman T, Dammerman R, Kriegstein A . Neurons derived from radial glial cells establish radial units in neocortex. Nature. 2001; 409(6821):714-20. DOI: 10.1038/35055553. View

17.

Kelly D, Rizzino A . DNA microarray analyses of genes regulated during the differentiation of embryonic stem cells. Mol Reprod Dev. 2000; 56(2):113-23. DOI: 10.1002/(SICI)1098-2795(200006)56:2<113::AID-MRD1>3.0.CO;2-Q. View

18.

Pankratov Y, Ivanov A, Kolokoltsova T, Nechayeva Y, Radayeva I, Korochkin L . Cell-based therapy of chronic degenerative diseases of the central nervous system. Adv Exp Med Biol. 2003; 534:97-105. DOI: 10.1007/978-1-4615-0063-6_7. View

19.

Aleksandrova M, Poltavtseva R, Revishchin A, Korochkin L, Sukhikh G . [Development of human brain neural/progenitor cells after transplantation into the brain of adult rats]. Morfologiia. 2003; 123(3):17-20. View

20.

Palmer T, Ray J, Gage F . FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci. 1995; 6(5):474-86. DOI: 10.1006/mcne.1995.1035. View