Stem Cells and Neuroprotection: Understanding the Players

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2010 Oct 20

PMID 20957094

Citations 1

Authors

Virginia Pearce

Affiliations

Soon will be listed here.

Abstract

The use of neuroprotective therapies begs the question of how such therapies could affect preexisting stem cell populations within the host, as well as those introduced through cell-replacement therapy. Multiple mechanisms may mediate stem cell responses to neuroprotectants such as host/donor age and gender, cellular lineage/differentiation status, and mitochondrial dynamics. Current therapeutic sources for stem cells are embryonic, somatic, or induced pluripotent, with very little known about the effects of gender, age, cell type, and mitochondrial dynamics. With the advent of therapies to stimulate and recruit endogenous stem cells or transplant donor cells into damage areas in the hopes of recuperative regeneration of lost neurons, it is important to discuss mechanisms that dictate the winning players in the neuroprotection game. This review will focus on our current understanding of the characteristics of renewing stem cells that may affect neuroprotection.

Citing Articles

Reparative effects of neural stem cells in neonatal rats with hypoxic-ischemic injury are not influenced by host sex.

Ashwal S, Ghosh N, Turenius C, Dulcich M, Denham C, Tone B Pediatr Res. 2014; 75(5):603-11.

PMID: 24463490 PMC: 4404035. DOI: 10.1038/pr.2014.7.

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