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Inhibitory Activity of Cyclohexenyl Chalcone Derivatives and Flavonoids of Fingerroot, Boesenbergia Rotunda (L.), Towards Dengue-2 Virus NS3 Protease

Overview
Specialty Biochemistry
Date 2006 Apr 20
PMID 16621533
Citations 81
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Abstract

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.

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