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Opioidergic Changes in the Pineal Gland and Hypothalamus in Cluster Headache: a Ligand PET Study

Overview
Journal Neurology
Specialty Neurology
Date 2006 Apr 12
PMID 16606930
Citations 25
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Abstract

Using PET with the opioidergic ligand [11C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.

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