» Articles » PMID: 26264897

[Neuropathic Pain. How to Open the Blackbox]

Overview
Journal Schmerz
Date 2015 Aug 13
PMID 26264897
Authors
Affiliations
Soon will be listed here.
Abstract

This article, without presuming to be comprehensive, gives a brief outline of the development of research on neuropathic pain in Germany. Current clinical research on this subject focusses on the validation of human models, patient phenotyping, mechanism-based classification and treatment as well as on molecular pathomechanisms. This clinical research is based to a large extent on the work of several internationally recognized basic researchers in the 1990s. In particular, findings from system physiology led to the analysis of clinical phenotypes and the underlying pathophysiology. In parallel, basic research achieved international top levels through the development of innovative methods. Close cooperation, building of consortia and European networking made major contributions to the success of this research.

References
1.
Treede R, Magerl W . Multiple mechanisms of secondary hyperalgesia. Prog Brain Res. 2000; 129:331-41. DOI: 10.1016/S0079-6123(00)29025-0. View

2.
Michaux G, Magerl W, Anton F, Treede R . Experimental characterization of the effects of acute stresslike doses of hydrocortisone in human neurogenic hyperalgesia models. Pain. 2011; 153(2):420-428. DOI: 10.1016/j.pain.2011.10.043. View

3.
Obreja O, Ringkamp M, Turnquist B, Hirth M, Forsch E, Rukwied R . Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors. Pain. 2011; 152(9):2138-2146. DOI: 10.1016/j.pain.2011.05.021. View

4.
Drdla-Schutting R, Benrath J, Wunderbaldinger G, Sandkuhler J . Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration. Science. 2012; 335(6065):235-8. DOI: 10.1126/science.1211726. View

5.
Yosipovitch G, Greaves M, Schmelz M . Itch. Lancet. 2003; 361(9358):690-4. DOI: 10.1016/S0140-6736(03)12570-6. View