Temporal Pattern of Nerve Growth Factor Receptor Expression in Developing Cochlear and Vestibular Ganglia in Quail and Mouse

Overview

Journal Anat Embryol (Berl)

Specialties Anatomy & Histology
Reproductive Medicine

Date 1991 Jan 1

PMID 1660224

Citations 4

Authors

J Represa

T R Van De Water

P Bernd

Affiliations

Soon will be listed here.

Abstract

We have previously demonstrated the presence of specific receptors for nerve growth factor (NGF) in cochleovestibular ganglia of 72 h (stage 19-20) quail embryos, with a greater density of NGF receptors in the cochlear portion of the ganglion. The present study was conducted to determine the temporal pattern of NGF receptor expression in cochlear and vestibular ganglia throughout development, and was conducted in two species, quail and mouse. As in the quail, specific binding of 125I-NGF was detected in cochleovestibular ganglia of mouse embryos from an embryonic age equivalent to 72 h quail embryos (embryonic day 11, E11), with a similar concentration of 125I-NGF binding in the cochlear portion. Quantitative studies revealed that 125I-NGF binding continued to increase, in both cochlear and vestibular ganglia, for several days of development, and then began to decrease to minimal levels. Maximal levels were achieved at E7 in the quail, and E14 to E16 in the mouse, while minimal levels were reached by E13 in the quail, and E18 in the mouse. The level of 125I-NGF binding in cochlear ganglia was two to three times higher than in vestibular ganglia; a finding corroborated by radioautographic studies. In both quail and mouse, NGF receptors were more heavily concentrated in the ventromedial portion of the cochlear ganglion, adjacent to the cochlear duct; an area containing both support cells and peripheral neuronal processes. In the vestibular ganglion, 125I-NGF binding was more homogeneous, although small areas containing high densities of silver grains were observed. The presence of NGF receptors in cochlear and vestibular ganglia suggests that these ganglia may be responsive to and/or dependent upon NGF during their development.

Citing Articles

Transcription factors in inner ear development.

Corey D, Breakefield X Proc Natl Acad Sci U S A. 1994; 91(2):433-6.

PMID: 8290543 PMC: 42962. DOI: 10.1073/pnas.91.2.433.

Pattern of trkB protein-like immunoreactivity in vivo and the in vitro effects of brain-derived neurotrophic factor (BDNF) on developing cochlear and vestibular neurons.

Vazquez E, Van De Water T, Del Valle M, Vega J, Staecker H, Giraldez F Anat Embryol (Berl). 1994; 189(2):157-67.

PMID: 8010414 DOI: 10.1007/BF00185774.

Developmental changes in nerve growth factor (NGF) binding and NGF receptor proteins trkA and p75 in the facial nerve.

Vazquez E, Calzada B, Naves J, Garnacho S, Del Valle M, Vega J Anat Embryol (Berl). 1994; 190(1):73-85.

PMID: 7985814 DOI: 10.1007/BF00185848.

Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.

Pirvola U, Ylikoski J, Palgi J, Lehtonen E, Arumae U, Saarma M Proc Natl Acad Sci U S A. 1992; 89(20):9915-9.

PMID: 1409719 PMC: 50244. DOI: 10.1073/pnas.89.20.9915.

References

Raivich G, Kreutzberg G . The localization and distribution of high affinity beta-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [125I]beta-nerve growth factor. Neuroscience. 1987; 20(1):23-36. DOI: 10.1016/0306-4522(87)90003-0. View

Barbin G, Katz D, Chamak B, Glowinski J, Prochiantz A . Brain astrocytes express region-specific surface glycoproteins in culture. Glia. 1988; 1(1):96-103. DOI: 10.1002/glia.440010111. View

Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P . Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 1989; 341(6238):149-52. DOI: 10.1038/341149a0. View

Carbonetto S, Stach R . Localization of nerve growth factor bound to neurons growing nerve fibers in culture. Brain Res. 1982; 255(3):463-73. DOI: 10.1016/0165-3806(82)90011-6. View

Straznicky C, Rush R . The effect of nerve growth factor on developing primary sensory neurons of the trigeminal nerve in chick embryos. Anat Embryol (Berl). 1985; 171(1):91-5. DOI: 10.1007/BF00319058. View

Katz D, Erb M, Lillis R, Neet K . Trophic regulation of nodose ganglion cell development: evidence for an expanded role of nerve growth factor during embryogenesis in the rat. Exp Neurol. 1990; 110(1):1-10. DOI: 10.1016/0014-4886(90)90046-u. View

Hendry I . Cell division in the developing sympathetic nervous system. J Neurocytol. 1977; 6(3):299-309. DOI: 10.1007/BF01175193. View

Hamburger V, HAMILTON H . A series of normal stages in the development of the chick embryo. J Morphol. 2014; 88(1):49-92. View

Despres G, Giry N, ROMAND R . Immunohistochemical localisation of nerve growth factor-like protein in the organ of Corti of the developing rat. Neurosci Lett. 1988; 85(1):5-8. DOI: 10.1016/0304-3940(88)90418-1. View

10.

Hohn A, Leibrock J, Bailey K, Barde Y . Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 1990; 344(6264):339-41. DOI: 10.1038/344339a0. View

11.

Rosenthal A, Goeddel D, Nguyen T, Lewis M, Shih A, Laramee G . Primary structure and biological activity of a novel human neurotrophic factor. Neuron. 1990; 4(5):767-73. DOI: 10.1016/0896-6273(90)90203-r. View

12.

Fink D, Morest D . Formation of synaptic endings by colossal fibers in the vestibular epithelium of the chick embryo. Neuroscience. 1977; 2(2):229-52. DOI: 10.1016/0306-4522(77)90091-4. View

13.

Yan Q, Johnson Jr E . An immunohistochemical study of the nerve growth factor receptor in developing rats. J Neurosci. 1988; 8(9):3481-98. PMC: 6569432. View

14.

Lillien L, Claude P . Nerve growth factor is a mitogen for cultured chromaffin cells. Nature. 1985; 317(6038):632-4. DOI: 10.1038/317632a0. View

15.

Represa J, Miner C, Barbosa E, Giraldez F . Bombesin and other growth factors activate cell proliferation in chick embryo otic vesicles in culture. Development. 1988; 103(1):87-96. DOI: 10.1242/dev.103.1.87. View

16.

Finn P, Ferguson I, Wilson P, Vahaviolos J, Rush R . Immunohistochemical evidence for the distribution of nerve growth factor in the embryonic mouse. J Neurocytol. 1987; 16(5):639-47. DOI: 10.1007/BF01637656. View

17.

Lefebvre P, Leprince P, Weber T, Rigo J, Delree P, Moonen G . Neuronotrophic effect of developing otic vesicle on cochleo-vestibular neurons: evidence for nerve growth factor involvement. Brain Res. 1990; 507(2):254-60. DOI: 10.1016/0006-8993(90)90279-k. View

18.

Van De Water T, Wersall J, Anniko M, Nordeman H . Development of the sensory receptor cells in the utricular macula. Otolaryngology. 1978; 86(2):ORL297-304. DOI: 10.1177/019459987808600222. View

19.

Ard M, Morest D, Hauger S . Trophic interactions between the cochleovestibular ganglion of the chick embryo and its synaptic targets in culture. Neuroscience. 1985; 16(1):151-70. DOI: 10.1016/0306-4522(85)90053-3. View

20.

Johnson Jr E, Taniuchi M, DiStefano P . Expression and possible function of nerve growth factor receptors on Schwann cells. Trends Neurosci. 1988; 11(7):299-304. DOI: 10.1016/0166-2236(88)90090-2. View