The Dictyostelium Kinome--analysis of the Protein Kinases from a Simple Model Organism

Overview

Journal PLoS Genet

Specialty Genetics

Date 2006 Apr 6

PMID 16596165

Citations 89

Authors

Jonathan M Goldberg

Gerard Manning

Allen Liu

Petra Fey

Karen E Pilcher

Yanji Xu

Janet L Smith

Affiliations

Soon will be listed here.

Abstract

Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced Drosophila. It contains members of most kinase classes shared by fungi and metazoans, as well as many previously thought to be metazoan specific, indicating that they have been secondarily lost from the fungal lineage. This includes the entire tyrosine kinase-like (TKL) group, which is expanded in Dictyostelium and includes several novel receptor kinases. Dictyostelium lacks tyrosine kinase group kinases, and most tyrosine phosphorylation appears to be mediated by TKL kinases. About half of Dictyostelium kinases occur in subfamilies not present in yeast or metazoa, suggesting that protein kinases have played key roles in the adaptation of Dictyostelium to its habitat. This study offers insights into kinase evolution and provides a focus for signaling analysis in this system.

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