Altered Expression of Vesicular Glutamate Transporters VGLUT1 and VGLUT2 in Parkinson Disease

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2006 Mar 28

PMID 16563567

Citations 61

Authors

Alireza Kashani

Catalina Betancur

Bruno Giros

Etienne Hirsch

Salah El Mestikawy

Affiliations

Soon will be listed here.

Abstract

Glutamatergic pathways play a key role in the functional organization of neuronal circuits involved in Parkinson disease (PD). Recently, three vesicular glutamate transporters (VGLUT1-3) were identified. VGLUT1 and VGLUT2 are responsible for the uploading of glutamate into synaptic vesicles and are the first specific markers of glutamatergic neurons available. Here, we analyzed the expression of VGLUT1 and VGLUT2 in autopsy tissues of PD patients and matched controls using Western blot and immunoautoradiography. VGLUT1 and VGLUT2 expression was increased in the Parkinsonian putamen by 24% and 29%, respectively (p<0.01). In contrast, only VGLUT1 was dramatically decreased in the prefrontal and temporal cortex of PD patients (approximately 50%, p<0.01 and p<0.001, respectively). These findings demonstrate the existence of profound alterations of glutamatergic transmission in PD, which are likely to contribute to the motor and cognitive impairments associated with the disease, and should thus be taken into account in the treatment of PD.

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References

Lange K, Kornhuber J, Riederer P . Dopamine/glutamate interactions in Parkinson's disease. Neurosci Biobehav Rev. 1997; 21(4):393-400. DOI: 10.1016/s0149-7634(96)00043-7. View

Anglade P, Mouatt-Prigent A, Agid Y, Hirsch E . Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease. Neurodegeneration. 1996; 5(2):121-8. DOI: 10.1006/neur.1996.0018. View

Sidibe M, Smith Y . Thalamic inputs to striatal interneurons in monkeys: synaptic organization and co-localization of calcium binding proteins. Neuroscience. 1999; 89(4):1189-208. DOI: 10.1016/s0306-4522(98)00367-4. View

Imon Y, Matsuda H, Ogawa M, Kogure D, Sunohara N . SPECT image analysis using statistical parametric mapping in patients with Parkinson's disease. J Nucl Med. 1999; 40(10):1583-9. View

Daniels R, Collins C, Gelfand M, Dant J, Brooks E, Krantz D . Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content. J Neurosci. 2004; 24(46):10466-74. PMC: 6730318. DOI: 10.1523/JNEUROSCI.3001-04.2004. View

Drouot X, Oshino S, Jarraya B, Besret L, Kishima H, Remy P . Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation. Neuron. 2004; 44(5):769-78. DOI: 10.1016/j.neuron.2004.11.023. View

Wilson N, Kang J, Hueske E, Leung T, Varoqui H, Murnick J . Presynaptic regulation of quantal size by the vesicular glutamate transporter VGLUT1. J Neurosci. 2005; 25(26):6221-34. PMC: 6725055. DOI: 10.1523/JNEUROSCI.3003-04.2005. View

Fremeau Jr R, Voglmaier S, Seal R, Edwards R . VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci. 2004; 27(2):98-103. DOI: 10.1016/j.tins.2003.11.005. View

Wojcik S, Rhee J, Herzog E, Sigler A, Jahn R, Takamori S . An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A. 2004; 101(18):7158-63. PMC: 406482. DOI: 10.1073/pnas.0401764101. View

10.

Fremeau Jr R, Kam K, Qureshi T, Johnson J, Copenhagen D, Storm-Mathisen J . Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004; 304(5678):1815-9. DOI: 10.1126/science.1097468. View

11.

Smith Y, Raju D, Pare J, Sidibe M . The thalamostriatal system: a highly specific network of the basal ganglia circuitry. Trends Neurosci. 2004; 27(9):520-7. DOI: 10.1016/j.tins.2004.07.004. View

12.

Klockgether T . Parkinson's disease: clinical aspects. Cell Tissue Res. 2004; 318(1):115-20. DOI: 10.1007/s00441-004-0975-6. View

13.

Lees A, Smith E . Cognitive deficits in the early stages of Parkinson's disease. Brain. 1983; 106 (Pt 2):257-70. DOI: 10.1093/brain/106.2.257. View

14.

Carlsson M, Carlsson A . The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm. 1989; 75(3):221-6. DOI: 10.1007/BF01258633. View

15.

Girault J, Raisman-Vozari R, Agid Y, Greengard P . Striatal phosphoproteins in Parkinson disease and progressive supranuclear palsy. Proc Natl Acad Sci U S A. 1989; 86(7):2493-7. PMC: 286939. DOI: 10.1073/pnas.86.7.2493. View

16.

Cummings J . Intellectual impairment in Parkinson's disease: clinical, pathologic, and biochemical correlates. J Geriatr Psychiatry Neurol. 1988; 1(1):24-36. DOI: 10.1177/089198878800100106. View

17.

Albin R, Young A, Penney J . The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989; 12(10):366-75. DOI: 10.1016/0166-2236(89)90074-x. View

18.

Sadikot A, Parent A, Francois C . The centre médian and parafascicular thalamic nuclei project respectively to the sensorimotor and associative-limbic striatal territories in the squirrel monkey. Brain Res. 1990; 510(1):161-5. DOI: 10.1016/0006-8993(90)90746-x. View

19.

Smith A, Bolam J . The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. Trends Neurosci. 1990; 13(7):259-65. DOI: 10.1016/0166-2236(90)90106-k. View

20.

DeLong M . Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 1990; 13(7):281-5. DOI: 10.1016/0166-2236(90)90110-v. View