Role of Cell Wall Structure of Salmonella in the Interaction with Phagocytes

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1970 Sep 1

PMID 16557832

Citations 13

Authors

D Friedberg

M Shilo

Affiliations

Soon will be listed here.

Abstract

Wild-type and cell wall mutants of Salmonella were examined for sensitivity to ingestion and intracellular killing in vitro by mouse peritoneal macrophages and guinea pig polymorphonuclear leukocytes. A complete polysaccharide core of the cell wall is important for resisting ingestion and intracellular killing, and the presence of the O-specific side chains contributes further resistance. Uridine diphosphate-gal-4-epimeraseless mutants grown on galactose-supplemented medium, rendering them smooth phenotypes, showed resistance to ingestion and intracellular killing similar to the wild type.

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