Nedocromil Sodium Inhibits Airway Hyperresponsiveness and Eosinophilic Infiltration Induced by Repeated Antigen Challenge in Guinea-pigs

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1991 Aug 1

PMID 1655142

Citations 4

Authors

R R Schellenberg

K Ishida

R J Thomson

Affiliations

Soon will be listed here.

Abstract

1. Repeated exposure to ovalbumin aerosol produced significant increases in epithelial eosinophils of airways of all sizes and produced increased pulmonary resistance (RL) to inhaled acetylcholine (ACh) in guinea-pigs. 2. Nedocromil sodium 10 mg ml-1, by nebulization prior to each ovalbumin (OA) challenge inhibited both the airway eosinophilia and hyperresponsiveness to ACh. 3. Nedocromil sodium pretreatment (10 mg ml-1 by nebulization) 10 min prior to OA completely inhibited the acute bronchoconstrictor response to OA. 4. Our findings suggest that nedocromil sodium inhibits airway hyperresponsiveness by inhibiting eosinophilic infiltration, or by simultaneously inhibiting mechanisms involved in both processes.

Citing Articles

Effects of IZP-94005 (contignasterol) on antigen-induced bronchial responsiveness in ovalbumin-sensitized guinea-pigs.

Bramley A, Langlands J, Jones A, Burgoyne D, Li Y, Andersen R Br J Pharmacol. 1995; 115(8):1433-8.

PMID: 8564202 PMC: 1908893. DOI: 10.1111/j.1476-5381.1995.tb16634.x.

Role of leukotrienes in airway hyperresponsiveness in guinea-pigs.

Ishida K, Thomson R, Schellenberg R Br J Pharmacol. 1993; 108(3):700-4.

PMID: 8467358 PMC: 1908060. DOI: 10.1111/j.1476-5381.1993.tb12864.x.

Nedocromil sodium. An updated review of its pharmacological properties and therapeutic efficacy in asthma.

Brogden R, Sorkin E Drugs. 1993; 45(5):693-715.

PMID: 7686465 DOI: 10.2165/00003495-199345050-00007.

Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs.

FARMER S, Wilkins D, Meeker S, Seeds E, Page C Br J Pharmacol. 1992; 107(3):653-9.

PMID: 1335332 PMC: 1907780. DOI: 10.1111/j.1476-5381.1992.tb14502.x.

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