GABAA Receptors Are Differentially Sensitive to Zinc: Dependence on Subunit Composition

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1991 Aug 1

PMID 1655141

Citations 77

Authors

T G Smart

S J Moss

X Xie

R L Huganir

Affiliations

Soon will be listed here.

Abstract

GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the gamma subunit were inhibited by zinc. Embryonic neurons also exhibited zinc-sensitive GABA responses, in contrast to adult neurones. This developmentally-sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the gamma subunit.

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References

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