Protease Digestion of Hepatitis A Virus: Disparate Effects on Capsid Proteins, Antigenicity, and Infectivity

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1991 Oct 1

PMID 1654460

Citations 2

Authors

S M Lemon

E Amphlett

D Sangar

Affiliations

Soon will be listed here.

Abstract

High concentrations of either trypsin or chymotrypsin caused nearly complete cleavage of capsid protein VP2 of hepatitis A virus but did not significantly reduce the infectivity, thermostability, or antigenicity of the virus. Chymotrypsin also had a lesser effect on VP1. These findings indicate the presence of a protease-accessible VP2 surface site which neither contributes significantly to the dominant antigenic site nor plays a role in the attachment of the virus to putative cell receptors.

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