Mouse Plasmacytoid Dendritic Cells Derive Exclusively from Estrogen-resistant Myeloid Progenitors

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2006 Mar 2

PMID 16507769

Citations 23

Authors

Benjamin C Harman

Juli P Miller

Neda Nikbakht

Rachel Gerstein

David Allman

Affiliations

Soon will be listed here.

Abstract

Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP(+) CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that PDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs.

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